探索原发性痛经患者大脑自发性活动的动态性及一致性变化

Exploratory Research of Dynamic Feature and Concordance Changes of Brain Spontaneous Activity in Patients with Primary Dysmenorrhea

目的探索原发性痛经(Primary Dysmenorrhea,PDM)患者大脑自发性活动的动态特征及各个指标间的一致性变化。方法采集36例PDM患者及41例健康人群的静息态功能磁共振数据。应用滑动时间窗技术,对低频振荡振幅(Amplitude of Low Frequency Fluctuations,ALFF)、局部一致性(Regional Homogeneity,ReHo)、体素-镜像同伦功能连接、度中心度及全局信号相关等5个指标进行分析,探索两组间各个指标的动态性及一致性差异。结果相比健康人群,PDM患者表现出ALFF的动态性增高,主要位于左侧颞叶、小脑半球、海马及右侧缘上回。同时患者表现出ReHo动态性增高,涉及脑区有左侧前额叶及直肌、右侧杏仁核、海马及海马旁回、颞下回,而动态性减低位于左侧颞中回。PDM患者各个指标间一致性变化与健康人群无统计学差异。结论PDM患者存在ALFF和ReHo的动态性异常,有可能为解释月经痛产生及调节的病理机制提供新的角度及客观证据。

Objective To explore dynamic feature and concordance changes of brain spontaneous activity in patients with primary dysmenorrhea(PDM).Methods Resting state fMRI data were collected from thirty-six patients with PDM and forty-one healthy people.Using the sliding time window technique,we analyzed the dynamic feature and concordance changes between five indicators in two groups including amplitude of low frequency fluctuations(ALFF),regional homogeneity(ReHo),voxel-mirrored homotopic connectivity,degree centrality and global signal correlation.Results Compared with healthy people,PDM patients showed the dynamic increase in ALFF mainly located in the left temporal lobe,cerebellar hemisphere,hippocampus and right superior marginal gyrus.At the same time,the patients demonstrated the dynamic increase in ReHo involving the left prefrontal lobe and rectus muscle,right amygdala,hippocampus and parahippocampal gyrus,inferior temporal gyrus,while the dynamic decrease was found in the left middle temporal gyrus.There was no statistical difference between two groups.Conclusion The dynamic abnormality of ALFF and ReHo was observed in PDM patients,which may provide a new perspective and objective evidence to explain the pathological mechanism of menstrual pain production and regulation.