氨甲环酸联合医用黄褐斑贴敷料治疗黄褐斑的疗效观察

Effect of tranexamic acid combined with Xi Yu chloasma application on chloasma

目的观察氨甲环酸联合医用黄褐斑贴敷料治疗黄褐斑的临床疗效。方法选取2020年1月至2021年1月共90例就诊于我院的黄褐斑患者,随机分为氨甲环酸组、敷贴组及联合组,每组各30例,疗程均为16周。观察治疗前、治疗后及治疗结束6月后随访时,患者皮损恢复情况,评估临床疗效,并且记录不良反应。结果疗程结束后,联合组医生整体评价(physician′s global assessment,PGA)及黄褐斑皮损面积和严重度指数(MASI)评分均显著低于氨甲环酸组及敷贴组,差异有统计学意义(P均<0.05)。结论氨甲环酸联合医用黄褐斑贴敷料治疗黄褐斑具有较好的疗效,可明显改善皮损颜色及缩小皮损面积,具有较好的临床疗效。

Objective To observe the clinical effect of tranexamic acid combined with Xi Yu chloasma application on chloasma.Methods A total of 90 patients with chloasma treated in our hospital from January 2020 to January 2021 were selected and randomly divided into the carbexamic acid group,the application group and the combined group,30 cases in each group,the course of treatment was 16 weeks.The recovery of skin lesions was observed before treatment,after treatment and 6 months after the end of treatment.The clinical efficacy was evaluated and adverse reactions were recorded.Results After treatment,the scores of physician's Global assessment(PGA)and melasma lesions area and severity index(MASI)in combined group were significantly lower than those in tranexamic acid group and application group,the differences were statistically significant(P<0.05).Conclusion Tranexamic acid combined with Xi Yu chloasma dressing has a good therapeutic effect on chloasma,which can obviously improve the skin color and reduce the skin area which has a good clinical effect on chloasma.