摘要
Caveolae,the specialized cell-surface plasma membrane invaginations which are abundant in endothelial cells,play critical roles in regulating various cellular processes,including cholesterol homeostasis,nitric oxide production,and signal transduction.Endothelial caveolae serve as a membrane platform for compartmentalization,modulation,and integration of signal events associated with endothelial nitric oxide synthase,ATP synthaseβ,and integrins,which are involved in the regulation of endothelial dysfunction and related cardiovascular diseases,such as atherosclerosis and hypertension.Furthermore,these dynamic microdomains on cell membrane are modulated by various extracellular stimuli,including cholesterol and flow shear stress.In this brief review,we summarize the critical roles of caveolae in the orchestration of endothelial function based on recent findings as well as our work over the past two decades.
基金
supported by National Key Research and Development Program of China Grant(2019YFA0802003)
National Natural Science Foundation of China Grants(81730014,81790621,82070451,and 81870313)
Young Elite Scientists Sponsorship Program by CAST(2019QNRC001)
Tianjin Municipal Science and Technology Project(18JCZDJC44900 and 17JCJQJC45700)。
