摘要
目的:探讨新诊断2型糖尿病(T2DM)患者五种血清脂肪因子水平与腹部脂肪之间的相关性。方法:连续性纳入2019-06-2020-12于我院门诊或住院发现的108例肥胖新诊断T2DM患者,70例年龄和体重相符的非糖尿病体检患者作为对照组。所有纳入受检者均检测血清丝氨酸蛋白酶抑制剂(VAS)、脂联素(APN)、脂肪素(APE)、白脂素(ASP)和网膜素-1(OMEN)五种经典的脂肪因子水平,腹部超声评价内脏脂肪组织(VAT)和皮下脂肪组织(SAT),并计算内脏脂肪指数(VAI)。比较两组对象以上各指标的差异,并分析新诊断T2DM患者VAT与血清脂肪因子、SAT、VAI的相关性。结果:新诊断T2DM组患者糖化血红蛋白(HbA1c)、空腹血糖和胰岛素抵抗指数(HOMA-IR)均明显高于对照组(P<0.05)。新诊断T2DM组患者APN和OMEN水平均明显低于对照组(P<0.01),而VAS、APE和ASP水平明显高于对照组(P<0.01)。相关性分析提示VAT与APE的相关系数最大(r=0.412,P<0.01;r_(调整年龄)=0.425,P<0.01;r_(调整年龄+BMI)=0.372,P<0.01)。结论:新诊断T2DM伴肥胖患者血清脂肪因子水平和VAT水平均明显升高,其中脂肪因子APE与VAT最为相关。
Objective:To evaluate the relationship between five adipocytokines and abdominal adipose tissue in obesity patients with newly diagnosed type 2 diabetes mellitus(T2DM).Method:One-hundred and eight obesity patients with newly diagnosed T2DM and seventy age-and-weight matched controls without non-diabetes mellitus were enroll in this study.All the patients were tested the levels of vaspin(VAS),adiponectin(APN),apelin-13(APE),asprosin(ASP)and omentin-1(OMEN).Abdomen ultrasound was used to measured visceral adipose tissue(VAT)and subcutaneous adipose tissue(SAT).Results:The levels of HbA1c,fast glucose and HOMA-IR of newly diagnosed T2DM group were higher than those of control group(P<0.05).The levels of APN and OMEN in newly diagnosed T2DM group were lower than those in control group(P<0.01),while levels of VAS,APE and ASP were higher than those in control group(P<0.01).Correlation analysis showed that VAT was most closely related to APE(r=0.412,r_(age adjusted)=0.425,r_(age+BMI adjusted)=0.372,P<0.01).Conclusion:The levels of adipocytokines and VAT are elevated in obesity patients with newly diagnosed T2DM.APE is most closely related to VAT.
作者
张晓乐
刘春燕
白宁
李颖
毛春谱
ZHANG Xiao-le;LIU Chun-yan;BAI Ning;LI Ying;MAO Chun-pu(Department of Endocrinology, Jiangnan University Affiliated Hospital, Wuxi 214125, China)
出处
《微循环学杂志》
2022年第1期45-49,共5页
Chinese Journal of Microcirculation
基金
无锡市卫健委科研项目(M202111)。
关键词
新诊断2型糖尿病
肥胖
脂肪因子
腹部脂肪
相关性
Newly diagnosed type 2 diabetes mellitus
Adipocytokines
Abdominal adipose tissue
Relationship