从微血管周细胞解析络脉功能的研究思路探讨

Discussion on the Research Ideas of Collateral Function from Microvascular Pericytes

络脉是中医重要理论基础之一,对其机制进行的研究取得了丰硕的成果。神经、内分泌、免疫和微循环构成的网络对组织细胞的微环境进行统筹调整,与络脉的功能和结构相似。符合生物-心理-社会医学模式,也符合中医“天人相应”的整体观。周细胞作为微血管调控核心成员,具备多种能力,参与并适应微环境的调整。周细胞现象,具有中医理论“阴阳”、“化”、“调和”等哲学特色,是中西医结合的一个切入点。在中医哲学智慧的指导下,将络脉理论与现代生物医学技术相结合,从周细胞的角度解析络脉功能及在病理生理过程中的作用,将有望对络脉相关疾病做出新的阐释,也为“通络”治疗的环节和靶点提供依据和思路。

Collaterals are one of the important theoretical basis of traditional Chinese medicine,and the research on its mechanism has achieved fruitful results.The network composed of nerve,endocrine,immune and microcirculation is similar to that of collaterals in function and structure,which can adjust the microenvironment of tissue cells.It is in accordance with the biological psychological social medical model and the holistic view of"correspondence between man and nature".As a core member of microvascular regulation,pericytes have many abilities to adapt and participate in the regulation of microenvironment.Pericyte phenomenon,with the philosophical characteristics of traditional Chinese medicine theory such as"Yin and Yang","transformation"and"harmony",is a suitable starting point for the integration of Chinese and Western medicine.Under the guidance of the wisdom of traditional Chinese medicine philosophy,combining collateral theory with modern biomedical technology,analyzing the function of collaterals and its role in pathophysiological process from the perspective of pericytes will be expected to make a new explanation of collaterals,and also provide basis and ideas for the links and targets of"dredging collaterals".