ACE基因I/D多态性与射血分数保留的心力衰竭患者左心室肥厚的关系研究

The relationship between ACE gene I/D polymorphism and left ventricular hypertrophy in heart failure patients with preserved ejection fraction

目的探讨血管紧张素转换酶(ACE)基因多态性与射血分数保留的心力衰竭(HFPEF)患者左心室肥厚(LVH)的关系。方法选择2018年1月至2019年12月温州医科大学附属苍南医院临床诊断为HFPEF的患者152例,根据左心室质量指数(LVMI)水平将其分为观察组和对照组,各76例。采用聚合酶链式反应(PCR)法确定ACE基因的插入/缺失(I/D)多态性,比较两组患者的基因型亚组(I/I、I/D和D/D)和等位基因(I和D)频率。结果与对照组比较,观察组患者D等位基因更普遍(P<0.05)。在加性和隐性模型下,两组基因型分布比较差异均有统计学意义(均P<0.05)。结论ACE基因的D等位基因可能与HFPEF患者LVH的发生有关。

Objective To investigate the relation between angiotensin-converting enzyme(ACE)gene polymorphism and left ventricular hypertrophy(LVH)in patients with heart failure with preserved ejection fraction(HFPEF).Methods One hundred and fifty-two patients with HFPEF from January 2018 to December 2019 in Cangnan Hospital,Wenzhou Medical University were enrolled and divided into observation group and control group based on left ventricular mass index(LVMI),with 76 cases in each group.The polymerase chain reaction(PCR)method was used to determine the insertion/deletion(I/D)polymorphism of ACE gene.The genotype subgroups(I/I,I/D,and D/D)and allele(I and D)frequencies were compared between the two groups.Results Compared with control group,D allele was more prevalent in observation group(P<0.05).There was a significant difference in the distribution of genotypes between the two groups under log-additive genetic model and recessive genetic model(all P<0.05).Conclusion D allele of ACE gene may be related to the occurrence of LVH in HFPEF patients.