甘精胰岛素联合瑞格列奈治疗2型糖尿病患者的临床效果

Clinical Effect of Insulin Glargine Combined with Repaglinide in the Treatment of Type 2 Diabetes Mellitus

目的评价糖尿病(2型)患者采取甘精胰岛素联合瑞格列奈治疗的可行性与降糖效果,为糖尿病患者临床用药提供参考。方法选择医院2017年10月至2018年12月收治的2型糖尿病患者80例。结合不同的治疗方法将80例2型糖尿病患者进行分组,对照组以及试验组患者分别采取常规预混胰岛素降糖治疗、甘精胰岛素联合瑞格列奈治疗。对比两组2型糖尿病患者治疗后血糖达标时间、血糖控制效果、胰岛素用量以及低血糖发生率。结果治疗后,试验组2型糖尿病患者血糖达标时间、胰岛素用量均少于对照组,血糖控制效果明显优于治疗前以及对照组,且低血糖发生率低于对照组,差异有统计学意义,P<0.05。结论对比常规预混胰岛素降糖治疗,甘精胰岛素联合瑞格列奈治疗2型糖尿病后降糖效果更佳,缩短了血糖达标时间,降低了胰岛素用药,且降低了患者的低血糖的发生风险,是优选用药方案。

Objective To evaluate the feasibility and hypoglycemic effect of insulin glargine combined with repaglinide in patients with diabetes mellitus(type 2),so as to provide a reference for clinical medication of diabetes patients.Methods A total of 80 type 2 diabetic patients who were admitted to our hospital from October 2017 to December 2018 were selected.The 80 patients with type 2 diabetes were divided into two groups according to the treatment method.The patients in the reference group and the experimental group were treated with conventional premixed insulin and insulin glargine combined with repaglinide respectively.The time of blood glucose reaching the standard,the effect of blood glucose control,the amount of insulin and the incidence of hypoglycemia were compared between the control group and the experimental group.Results After the treatment,the time of reaching the standard of blood glucose and the amount of insulin in the experimental group were less than those in the reference group,the effect of blood glucose control was significantly better than that before the treatment and the reference group,and the incidence of hypoglycemia was lower than that in the reference group,the difference was significant(P<0.05).Conclusion Compared with the conventional premixed insulin,insulin glargine combined with repaglinide has better hypoglycemic effect,shortens the time of reaching the standard of blood glucose,reduces the use of insulin,and reduces the risk of hypoglycemia.