白蛋白改善早产儿凝血功能和血清蛋白水平的临床意义

Clinical significance of albumin in improving coagulation function and serum protein in premature infants

目的:探讨白蛋白对于改善早产儿凝血功能和血清蛋白水平的临床意义。方法:选择早产儿100例,根据随机数表法分为联合组和对照组,对照组早产儿给予外周静脉营养和早期微量肠内喂养治疗,联合组在对照组基础上给予白蛋白进行联合治疗,比较2组早产儿营养恢复状况,对2组治疗后凝血功能各指标进行比较,观察2组治疗前后血清总蛋白、血红蛋白和白蛋白水平,比较2组治疗前后血糖、尿素氮和总胆红素水平,统计2组早产儿喂养耐受及并发症发生情况。结果:联合组早产儿体质量恢复到正常时间和按需哺乳的时间均短于对照组,体质量每天增加水平高于对照组(P<0.01);治疗后,联合组早产儿活化部分凝血酶原时间、凝血酶原时间、凝血酶时间、纤维蛋白原水平均低于对照组,FIB水平均高于对照组(P<0.01);治疗前,2组早产儿血清总蛋白、血红蛋白、白蛋白、血糖、尿素氮和总胆红素水平差异均无统计学意义(P>0.05),治疗后联合组早产儿血清总蛋白、血糖、尿素氮和总胆红素水平均高于对照组(P<0.01),血红蛋白和白蛋白水平2组差异无统计学意义(P>0.05),且治疗前后,除了对照组血糖差异无统计学意义(P>0.05),联合组血糖、2组尿素氮、总胆红素、血糖、尿素氮和总胆红素水平治疗后均高于治疗前(P<0.05~P<0.01);联合组早产儿喂养耐受率高于对照组,并发症总发生率低于对照组(P<0.01和P<0.05)。结论:白蛋白对于改善早产儿凝血功能的和血清蛋白临床效果显著,可明显改善早产儿血糖、尿素氮和总胆红素水平,且并发症较少。

Objective:To explore the clinical significance of albumin in improving coagulation function and serum protein of premature infants.Methods:One hundred premature infants were divided into the combined group and control group according to the random number table method.The control group was treated with peripheral vein nutrition combined with early micro enteral feeding,and the combined group was treated with albumin based on the control group.The nutritional recovery of preterm infants was compared between two groups,and the indicators of coagulation function between two goups after treatment were compared.The serum levels of total protein,hemoglobin and albumin in two groups before and after treatment were observed.The blood glucose,urea nitrogen and total bilirubin levels before and after treatment were compared between two groups,and the feeding tolerance and complications in two groups were analyzed.Results:The time of the body mass recovering to normal and feeding time as needed in combined group were shorter than those in control group,and the daily increasing of body mass in combined group was higher than that in control group(P<0.01).After treatment,the levels of APTT,PT and TT in combined group were lower than those in control group,and the FIB level in combined group was higher than that in control group(P<0.01).Before treatment,the differences of the serum levels of total protein,hemoglobin,albumin,blood glucose,urea nitrogen and total bilirubin were not statistically significant between two groups(P>0.05).After treatment,the serum levels of total protein,blood glucose,urea nitrogen and total bilirubin in combined group were higher than those in control group(P<0.01),the differences of the levels of hemoglobin and albumin between two groups were not statistically significant(P>0.05),and there was no statistical significance in the blood glucose level between before and after treatment in control group(P>0.05).The serum levels of blood glucose in combined group,and urea nitrogen,total bilirubin,blood glucose,urea nitrogen and total bilirubin in two groups after treatment were higher than those before treatment(P<0.05 to P<0.01).The tolerance rate of premature infant feeding in combined group was higher than that in control group,and the total incidence rate of complications in combined group was lower than that in control group(P<0.01 and P<0.05).Conclusions:Albumin has a significant clinical effect on improving the coagulation function and serum protein of preterm infants.It can significantly improve the blood glucose,urea nitrogen and total bilirubin levels of preterm infants,and has fewer complications.