镇静深度及深度镇静持续时间对ICU重症急性胰腺炎病人谵妄发生的影响

Effect of the depth of sedation and duration of deep sedation on occurrence of delirium in ICU patients with severe acute pancreatitis

目的:探讨急性重症胰腺炎(severe acute pancreatitis,SAP)病人镇静深度及深度镇静持续时间对其发生谵妄的影响。方法:回顾性分析接受治疗的SAP病人258例,以病人在ICU结束治疗作为研究终点,根据是否发生谵妄将病人分为谵妄组和非谵妄组,比较2组病人镇静深度及深度镇静时间。结果:谵妄组镇静深度率及深度镇静持续时间均大于非谵妄组,差异均有统计学意义(P<0.01)。结论:ICU SAP病人镇静深度越深、深度镇静时间越长,其谵妄发生率也越高。

Objective:To explore the effects of the depth of sedation and duration of deep sedation on occurrence of delirium in patients with severe acute pancreatitis(SAP).Methods:The clinical data of 258 patients with SAP were retrospectively analyzed.The end of treatment in ICU of patients was set as the study endpoint,the patients were divided into the delirium group and non-delirium group.The depth of sedation and duration of deep sedation between two groups were compared.Results:The depth of sedation and duration of deep sedation in delirium group were greater than those in non-delirium group(P<0.01).Conclusions:The deeper sedation depth and the longer sedation time in ICU patients with SAP,the higher the incidence rate the delirium is.