2型糖尿病并发肺部感染患者mFI与患者高炎性状态、免疫功能失调的相关性分析

Correlation Analysis of MFI with Hyperinflammatory State and Immune Dysfunctionin Patients with Type 2 Diabetes Mellitus Complicated with Pulmonary Infection

目的:分析2型糖尿病并发肺部感染患者改良衰弱指数(mFI)与患者高炎性状态、免疫功能失调的相关性。方法:按照有无肺部感染将110例2型糖尿病患者分为未感染组(75例)和感染组(35例),对入院时的mFI、免疫功能指标、血清炎症因子、肺功能指标水平进行比较。结果:与未感染组相比,感染组的mFI评分、CD4+/CD8+、CD3+、CD4+水平、各项血清炎症因子水平均明显升高(P<0.05),FEV1、MVV、MMEF、FRC水平均明显降低(P<0.05)。Pearson相关性分析结果显示,2型糖尿病并发肺部感染患者的mFI评分与MVV、FEV1表现为负相关,与血清CD3+、PCR、CRP表现为正相关。结论:2型糖尿病并发肺部感染患者的mFI评分与高炎性状态、免疫功能失调存在显著的相关性,临床中应对2型糖尿病患者进行严格管理。

Objective:To analyze the correlation between modified weakness index(mFI)and high inflammatory state,immune dysfunction in patients with type 2 diabetes mellitus complicated with pulmonary infection.Methods:110 patients with type 2 diabetes were divided into non infection group(75 cases)and infection group(35 cases)according to the presence or absence of pulmonary infection.The levels of mFI,immune function indicators,serum inflammatory factors,and lung function indicators at admission were compared.Results:Compared with the non infection group,the mFI score,the levels of CD4+/CD8+,CD3+,CD4+and serum inflammatory factors in the infection group were significantly increased(P<0.05),while the levels of FEV1,MVV,MMEF and FRC were significantly decreased(P<0.05).Pearson correlation analysis showed that the mFI score was negatively correlated with MVV and FEV1,and positively correlated with serum CD3+,PCR and CRP in patients with type 2 diabetes mellitus complicated with pulmonary infection.Conclusion:The MFI score of patients with type 2 diabetes mellitus complicated with pulmonary infection is significantly correlated with high inflammatory state and immune dysfunction,so strict management should be carried out in patients with type 2 diabetes mellitus.