甲巯咪唑联合比索洛尔对甲亢患者的治疗效果及不良反应率分析

Analysis of Therapeutic Effect and the Incidence of Adverse Reactions of Thiamazole Combined with Bisoprolol in Patients with Hyperthyroidism

目的:分析甲亢患者口服甲巯咪唑联合比索洛尔的治疗效果及不良反应发生率。方法:回顾性选取2019年6月~2021年6月某院甲亢患者60例,依据治疗方法分为甲巯咪唑联合比索洛尔治疗组(联合治疗组)和甲巯咪唑单独治疗组(单独治疗组)各30例,统计分析两组患者的甲状腺素水平、临床疗效、不良反应发生情况。结果:两组患者治疗后的TSH、FT3、FT4、T3、T4水平均低于治疗前(P<0.05);治疗后,联合治疗组患者的TSH、FT3、FT4、T3、T4水平均低于单独治疗组(P<0.05)。联合治疗组患者治疗的总有效率96.67%(29/30)高于单独治疗组73.33%(22/30)(P<0.05)。联合治疗组和单独治疗组患者的不良反应发生率分别为33.33%(10/30)、40.00%(12/30),两组差异不显著(P>0.05)。结论:甲亢患者口服甲巯咪唑联合比索洛尔的治疗效果较单独口服甲巯咪唑好,且不会提升患者不良反应发生率。

Objective:To analyze the therapeutic effect and the incidence of adverse reactions of thiamazole combined with bisoprolol in patients with hyperthyroidism.Methods:Sixty patients with hyperthyroidism in a hospital from June 2019 to June 2021 were retrospectively selected and divided into thiamazole combined with bisoprolol treatment group(combined treatment group)and thiamazole alone treatment group(single treatment group)according to treatment methods,with 30 cases in each group.Then the levels of thyroid hormone levels,clinical efficacy and the incidence of adverse reactions in the two groups were statistically analyzed.Results:The levels of TSH,FT3,FT4,T3 and T4 in the two groups after treatment were lower than those before treatment(P<0.05);After treatment,TSH,FT3,FT4,T3 and T4 levels of patients in the combined treatment group were lower than those in the single treatment group(P<0.05).The total efficiency of the combined treatment group was 96.67%(29/30),which was higher than that of the single treatment group(73.33%,22/30)(P<0.05).There was no significant difference in the incidence of between the combined treatment group(33.33%,10/30)and the single treatment group(40.00%,12/30)(P>0.05).Conclusion:Oral thiamazole combined with bisoprolol is better than oral thiamazole in patients with hyperthyroidism,and does not increase the incidence of adverse reactions.