低分子肝素钠+阿司匹林治疗复发性流产的临床应用价值

Clinical Value of Low Molecular Weight Heparin Sodium + Aspirin in the Treatmentof Recurrent Abortion

目的:分析复发性流产患者治疗期间应用低分子肝素钠联合阿司匹林的临床效果。方法:选取某院产科于2018年2月~2020年7月期间接收的76例复发性流产患者作为研究对象,采用随机数表分组法将76例患者分为参照组和研究组各38例,参照组采用阿司匹林口服治疗,研究组采用低分子肝素钠皮下注射联合阿司匹林口服治疗,比较两组的治疗效果、激素水平、凝血指标。结果:治疗后,研究组的孕酮水平为(30.15±3.28)μg/L、雌二醇为(526.41±23.48)ng/L,优于参照组的(21.89±3.14)μg/L、(426.15±22.61)ng/L(P<0.05);研究组的纤维蛋白原、血小板水平分别为(2.74±0.12)g/L、(185.69±21.56)×10^(9)/L,均优于参照组的(3.01±0.11)g/L、(152.12±20.25)×10^(9)/L(P<0.05);研究组的保胎成功率(84.21%)高于参照组(63.16%)(P<0.05);研究组的不良反应发生率(2.63%)低于参照组(15.78%)(P<0.05)。结论:复发性流产患者应用低分子肝素钠皮下注射联合阿司匹林口服治疗的效果显著,可以明显改善激素水平以及凝血指标,从而提高其保胎率。

Objective:To analyze the clinical effect of low molecular weight heparin sodium combined with aspirin in the treatment of patients with recurrent abortion.Methods:A total of 76 patients with recurrent abortion received ina hospital from February 2018 to July 2020 were selected as the research objects and divided into the reference group and the study group by random number table grouping method,with 38 patients in each group.The reference group was treated with aspirin orally,and the study group was given subcutaneous injection of low molecular weight heparin sodium combined with oral aspirin,then the therapeutic effect,hormone levels and coagulation indicators of the two groups were compared.Results:After treatment,the levels of progesterone and estradiol in the study group were(30.15±3.28)μg/L and(526.41±23.48)ng/L,which were better than those in the control group[(21.89±3.14)μg/L,(426.15±22.61)ng/L](P<0.05).The fibrinogen and platelet levels in the study group were(2.74±0.12)g/L and(185.69±21.56)×109/L,respectively,which were better than those in the control group[(3.01±0.11)g/L,(152.12±20.25)×109/L](P<0.05).The success rate of fetal preservation in the study group(84.21%)was higher than that in the reference group(63.16%)(P<0.05).The incidence of adverse reactions in study group (2.63%) was lower than that in control group (15.78%) ( P <0.05). Conclusion: Subcutaneous injection of low molecular weight heparin sodium combined with oral aspirin has significant effect on patients with recurrent abortion, which can significantly improve hormone levels and coagulation indexes, and thus improve the rate of fetal preservation.