吲哚菁绿荧光成像技术在口腔鳞癌治疗中的应用:中国专家共识

Chinese expert consensus statement on the application of of indocyanine green(ICG)fluorescence imaging in the treatment of oral squamous cell carcinoma

吲哚菁绿(indocyanine green,ICG)荧光成像是一种基于ICG增强的渗透性和滞留效应(enhanced permeability and retention effect,EPR)的活体组织实时近红外显像技术,临床上可对实体肿瘤及其周围组织进行差异显像,评估肿瘤范围及手术切缘。该荧光成像技术用于口腔鳞癌(oral squamous cell carcinoma,OSCC)外科治疗尚处于起步阶段,在适应证、操作流程、注意事项等方面均缺乏相应规范。在前期开展的ICG近红外荧光成像辅助OSCC外科治疗的多中心临床研究基础上,经国内多家医学院校口腔颌面外科专家的共同商讨,参考国内外相关文献,形成ICG荧光成像技术在OSCC治疗中的应用专家共识,以期指导OSCC外科治疗的临床实践。

Indocyanine green(ICG)is a near-infrared fluorescent dye.Based on the enhanced permeability and retention(EPR)effect,the ICG fluorescence imaging was applied extensively in biomedical fields.The technique could sensitively detect imaging difference between the tumor and surrounding tissue,and define the tumor border to assist in tumor resection.Nevertheless,the application in the treatment of oral squamous cell carcinoma(OSCC)is still at the neonate stage.Thereby,its indication,standard operation procedure and caution required normalization.On the Evidence-based approaches including multi-center study,systemic reviews of related scientific publications,the Chinese experts reach a consensus of ICG fluorescence imaging technique to instruct the clinical practice of OSCC surgery.