二甲双胍抗衰老临床研究与作用机制研究进展

Research Progress of Clinical Trial and Mechanism of Anti-aging Effect of Metformin

二甲双胍是一种安全有效的糖尿病治疗药物,除具有降糖作用外,还具有保护心脏、抗炎和抗癌等作用。近年来,多项细胞和动物实验结果显示,二甲双胍具有抗衰老作用,一些临床试验结果也证明二甲双胍对年龄相关疾病具有积极作用,包括心血管疾病、癌症和神经退行性疾病等。该文对二甲双胍抗衰老相关的临床试验分子机制进行综述,探索二甲双胍在抗衰老中的作用潜力。

Metformin is a safe and effective drug for diabetes.In addition to its hypoglycemic effect,it also has the effects of protecting heart,anti-inflammatory and anti-cancer.In recent years,a number of cell and animal experiments have shown that metformin has anti-aging effects.The results of some clinical trials have also proved that metformin has a positive effect on the prevalence of age-related diseases,including cardiovascular diseases,cancer and neurodegenerative diseases.This article reviews the molecular mechanisms and clinical trials of metformin,and explores the potential of metformin in anti-aging.