肝移植手术后患者应用伏立康唑状况调查

Investigation and Analysis of the Rational Use of Voriconazole in Patients After LiverTransplantation

目的调查和分析北京友谊医院肝移植手术后患者伏立康唑应用状况,为临床用药提供参考。方法回顾2016—2019年北京友谊医院肝移植手术后患者应用伏立康唑情况,根据药品说明书、临床用药须知、临床指南和相关文献,并与临床医师和临床药师讨论,评价用药合理性。结果纳入病历295份,其中<2岁患者103例(34.92%),超出说明书适应人群。192例适用人群中,6例(3.13%)预防性用药患者无用药指征,184例(95.83%)用法用量不适宜。结论肝移植手术后患者应用伏立康唑有待规范。<2岁儿童应用伏立康唑的用药方案、安全性和有效性有待进一步研究。应重视伏立康唑个体化用药,促进合理用药。

Objective To investigate and analysis the application status of voriconazole in patients after liver transplantation,and to provide reference for clinical medication.Methods A retrospective statistical analysis was conducted in hospitalized patients after liver transplantation using voriconazole from 2016 to 2019.After discussion with clinicians and clinical pharmacists,the rationality use of voriconazole was evaluated according to drug labels,instructions,Chinese pharmacopoeia,and clinical therapeutic guidelines and literatures.Results A total of 295 patients were included.And 103(34.92%)patients were less than 2 years old,younger than the recommended population in the drug label.In 192 cases of applicable population,6 cases(3.13%)had no indication of prophylactic drug use.A hundred and eighty-four cases(95.83%)were unsuitable for usage and dosage.Conclusion The clinical application of voriconazole in patients after liver transplantation need to be regulated.The dosage regimen,safety and efficacy of voriconazole in children younger than 2 years need to be further studied.It should be paid more attention to the blood concentration monitoring and individual medication.