一例抗磷脂综合征伴克罗恩病并发下肢深静脉血栓患者抗栓治疗分析

Analysis of antithrombotic therapy of a patient with antiphospholipid syndrome and Crohn’s disease complicated with deep venous thrombosis

目的:分析1例抗磷脂综合征伴克罗恩病并发下肢深静脉血栓病例的治疗过程,探讨抗栓药物选择的合理性,为临床合理用药提供参考。方法:临床药师协助医师依据患者自身疾病特点及实验室指标评估血栓及出血风险,并制订最优的抗栓治疗方案。结果和结论:患者初始抗栓药物为利伐沙班。临床药师根据循证医学证据建议换用华法林进行抗栓治疗,并针对抗栓强度及疗程提供建议。临床药师参与临床药物治疗,对患者实施了全面的药学服务,为保障患者用药的安全性和有效性发挥了积极作用。

Objective:To analyze the treatment of a case of antiphospholipid syndrome and Crohn’s disease complicated with deep venous thrombosis,and also to evaluate the rationality of antithrombotic drug selection,so as to provide reference for rational use of drugs.Methods:Depending on the disease characteristics of the patient and obtained laboratory data,clinical pharmacists assisted physicians to assess risks of thrombosis and hemorrhage,and develop optimal individualized anticoagulant profile.Results and Conclusion:The initial anticoagulant drug for the patient was rivaroxaban.With the help of evidence-based medical evidence,clinical pharmacists recommended to use warfarin for anticoagulant therapy and offered proposals on the intensity and course of anticoagulant therapy.Active involement of clinical pharmacists in clinical drug treatment facilitates comprehensive pharmaceutical care of patients,and they could play a positive role in the efficacy and safety of clinical medication.