ZnT8在胰腺癌发生和发展中的作用

The Role of ZnT8 in the Development and Progression of Pancreatic Cancer

本研究主要探索锌转运蛋白8(ZnT8)/溶质载体家族30成员8(SLC30A8)在胰腺癌的发生和发展中的作用.利用cBioPortal平台分析癌症基因组图谱(TCGA)数据库资料中胰腺癌患者的SLC30A8基因的拷贝数变异和突变情况、患者的预后生存情况、共表达基因;利用DAVID平台进行功能富集分析得到共表达基因的GO功能分类条目;通过STRING数据库分析蛋白质相互作用.结果发现,SLC30A8在患病人群中遗传发生改变的占9%;在总体生存期,无进展生存期和疾病特异性生存期中SLC30A8遗传改变组的生存率都显著低于未改变组的(p<0.05);SLC30A8参与了调节激素水平、肽激素分泌的调节和胰岛素分泌调节等生物过程.本研究为探索ZnT8在胰腺癌发生中的机制做了基础工作,并且该基因可能成为胰腺癌治疗的潜在靶点.

This study is to explore the role of zinc transporters 8(ZnT8)/the solute carrier family 30,member 8(SLC30A8)in the development and progression of pancreatic cancer.The copy number variation and mutation of SLC30A8 gene,survival analysis,and co-expression genes of pancreatic adenocarcinoma patients in The Cancer Genome Atlas(TCGA)database were analyzed by cBioPortal platform.The GO terms analysis of co-expression genes was obtained by functional enrichment analysis on DAVID platform;The protein-protein interaction was analyzed by STRING database.The results showed that genetic changes in SLC30A8 accounted for 9%of the patients.The overall survival,progression-free survival and disease-specific survival in the SLC30A8 genetic altered group were significantly lower than those in the unaltered group(p<0.05).SLC30A8 is involved in the regulation of hormone levels,peptide hormone secretion,insulin secretionand other processes.This study provides basic work for exploring the mechanism of ZnT8 in pancreatic cancer,and SLC30A8 gene may be a potential therapeutic target for pancreatic cancer.