上海地区成人维生素D水平与性别、年龄、季节的关系

Serum vitamin D levels in Shanghai adults:effects of gender,age and season

目的了解上海地区成人维生素D水平状况,探讨不同性别、年龄、季节对维生素D水平的影响。方法将21864例在上海市第六人民医院体检中心进行健康体检者作为研究对象进行回顾性研究,包括男性10566人,女性11298人。结果21864例研究对象的25(OH)D水平为19.68(15.12,25.48)ng/mL。其中维生素D缺乏、不足和正常的比例分别为51.66%、35.20%、13.14%。25(OH)D水平随年龄增长而升高,而维生素D缺乏率则相应下降(P<0.01)。18~29岁年龄组青年血清25(OH)D水平最低,维生素D缺乏率最高(男性57.94%,女性82.68%)。男性从60~69岁、女性从50~59岁开始,血清25(OH)D水平维持在稳定状态。无论男女,在夏季血清25(OH)D水平最高,冬季最低,夏秋两季的维生素D水平明显高于冬春两季(P<0.01)。各年龄组、任何季节,女性的维生素D水平均低于相应男性,维生素D缺乏率高于相应男性(P<0.01)。回归分析显示性别、年龄和季节影响维生素D水平变化。结论上海地区成人维生素D缺乏比较普遍,尤其多见于青年女性。维生素D水平变化与性别、年龄、季节相关联。

Objective The aim of the study was to determine the effects of gender,age and season on vitamin D status and serum vitamin D levels in Shanghai adults.Methods Serum 25-hydroxyvitamin D[25(OH)D]levels of 21864 participants:10566 men and 11298 women,applying to Shanghai Sixth People's Hospital for check were retrospectively analyzed.Results The median serum 25(OH)D concentration was 19.68(15.12,25.48)ng/mL.Overall,the prevalence of Vitamin D deficiency,insufficiency and sufficiency was 51.66%,35.20%and 13.14%,respectively.There was a significant trend(P<0.01)towards higher serum 25(OH)D concentration and lower prevalence of vitamin D deficiency with advancing age.Serum 25(OH)D concentration was the lowest among the 18-29 years of age group,whereas the prevalence of vitamin D deficiency was the highest(57.94%for men and 82.68%for women).From 60-69 years of age group in men and 50-59 years of age group in women,there were no significant differences in serum 25(OH)D concentration.A seasonal variation of 25(OH)D levels was observed in both genders with the highest levels in summer and the lowest in winter.Vitamin D levels in summer and autumn were significantly higher than those in winter and spring(P<0.01).Serum 25(OH)D concentrations were significantly higher in men compared to women in each age group and any season(P<0.01).And the prevalence of vitamin D deficiency was higher in women than that in men.Regression analysis showed that gender,age and season were associated with serum Vitamin D levels.Conclusion The prevalence of vitamin D deficiency is high,particularly in the young women.Changes in vitamin D levels were associated with gender,age and season.