肠道菌群及其代谢产物对高血压影响的研究进展

Research Progress in Influence of Intestinal Flora and Its Metabolites on Hypertension

肠道菌群及其代谢产物群体庞大、种类繁多,在各系统疾病中发挥不同的效应,对维持机体正常生理功能非常重要,是近年国内外学者研究的焦点之一。高血压作为危害性极高的慢性心血管疾病,发病率逐渐升高且发病年龄趋于年轻化,已成为世界性公共卫生问题。高血压的发病机制目前尚未明确,肠道菌群及其代谢产物均可能参与高血压的发病,因此调节肠道内环境可调控血压。未来深入研究肠道菌群及其代谢产物影响高血压的机制,可以为高血压的防治提供新靶点。

Intestinal microflora and its metabolites are large and diverse,and play different effects in various systemic diseases.They are very important for maintaining normal physiological functions of the body,and have become one of the research focuses at home and abroad in recent years.Hypertension,as a dangerous chronic cardiovascular disease,has become a worldwide public health problem with a gradually increasing incidence and younger onset age.The pathogenesis of hypertension is not yet clear,and intestinal flora and its metabolites may be involved,so regulating the intestinal environment can regulate blood pressure.In the future,in-depth study on the mechanism of intestinal microflora and its metabolites affecting hypertension can provide new targets for the prevention and treatment of hypertension.