母胎界面树突状细胞在病理性妊娠中的作用机制研究进展

Research Progress in Mechanism of Dendritic Cells on Maternal-fetal Interface in Pathological Pregnancy

妊娠过程中,母胎界面少量的树突状细胞(DC)即可与母胎界面其他细胞滋养细胞、自然杀伤细胞(NK细胞)、巨噬细胞、调节性T细胞(Treg细胞)等相互联系、相互影响,通过参与调控辅助性T细胞(Th细胞)1/Th2平衡、促进Treg细胞增殖、调控NK细胞等免疫耐受环节发挥重要的免疫耐受调控作用。此外,DC还可以表达一系列信号分子、细胞因子和趋化因子等,直接或间接参与调控蜕膜化、血管生成、胎盘形成等过程。而DC的数量、分化和功能异常会直接或间接导致各种病理性妊娠,如自然流产、先兆子痫、HELLP综合征、异位妊娠等。

During pregnancy,a small number of dendritic cell(DC)on the maternal-fetal interface,through mutual connection and influence with other cells on the interface[trophoblasts,natural killer cell(NK cell),macrophages,regulatory T cell(Treg cell),etc.],play a crucial regulatory role in many immune tolerance links,such as regulating the balance of helper T(Th cell)1/Th2 cytokines,promoting the proliferation of Treg cell,regulating NK cell and so on.In addition,DC can also express a series of signaling molecules,cytokines and chemokines etc.,directly or indirectly involved in the process of decidualization,angiogenesis and placenta formation.The abnormal quantity,differentiation and function of DC could directly or indirectly lead to various pathological pregnancy,such as spontaneous abortion,preeclampsia,HELLP syndrome,ectopic pregnancy,etc.