生命早期营养不良与成年期肥胖关系的研究进展

Research Progress in Correlation between Malnutrition in Early Life and Obesity in Adulthood

肥胖是一种慢性代谢性疾病,指多因素导致的体内过多脂肪堆积和(或)分布异常,严重危害机体健康,目前发病机制尚未明确。营养不良是饥荒暴露导致的最终结果之一,生命早期营养不良可能与成年期肥胖相关,目前的主要相关学说包括胎儿起源学说、节俭基因和表型假说等。通过饥荒暴露环境探讨生命早期营养不良与成年期肥胖之间的关系,有助于寻找生命早期营养不良与成年期肥胖之间的关系及其发生机制,将为肥胖的防治提供科学理论依据。

Obesity is a chronic metabolic disease,which refers to excessive fat accumulation and/or abnormal distribution in the body caused by multiple factors,seriously endangering the body′s health,and the pathogenesis is not clear so far.Malnutrition is one of the final results of famine exposure.Malnutrition in early life may be related to obesity in adulthood.At present,the main relevant theories include fetal origin theory,thrift gene and phenotype hypothesis.Exploration of the relationship between malnutrition in early life and obesity in adulthood through famine exposure environment is helpful to discvoer the relationship between and mechanism of malnutrition in early life and obesity in adulthood,which will provide a scientific theoretical reference for the prevention and treatment of obesity.