PCT升高在肾综合征出血热中的临床应用价值及机制

Clinical Value and Mechanisms of PCT Rise in Hemorrhagic Fever with Renal Syndrome

肾综合征出血热(HFRS)是一种由汉坦病毒感染引起的自然疫源性疾病,也是一种呈世界性流行的重要传染病。降钙素原(PCT)是监测细菌感染的重要指标,与细菌感染程度相关。PCT被广泛应用于脓毒血症、脑炎、肺炎等感染性疾病的临床监测,但其在HFRS患者中的临床应用价值却较少提及。PCT可辅助HFRS的早期诊断,且与疾病细菌感染程度及病情程度密切相关,具有重要的临床应用价值。同时,PCT的合成受多种因素影响,包括细胞因子、肾损害、血流动力学不稳定等,这些因素改变可导致HFRS患者PCT水平升高。因此,未来综合考虑多种影响因素,有助于鉴别是否存在细菌感染,从而避免HFRS患者过度使用抗生素。

Hemorrhagic fever with renal syndrome(HFRS)is a natural epidemic disease caused by Hantavirus infection,and it is an important worldwide prevalent infectious disease.Procalcitonin(PCT)is generally considered to be an important index to monitor bacterial infection,which is related to the degree of bacterial infection and is widely used in sepsis,meningitis,pneumonia and other infectious diseases.However,the clinical value of PCT in patients with renal comprehensive hemorrhagic fever has rarely been mentioned in the past.In fact,PCT can assist the early diagnosis of HFRS,and is closely related to the degree of bacterial infection and the degree of disease,and has a great clinical application value.At the same time,the synthesis of PCT is affected by many factors,including cytokines,renal damage,hemodynamic instability and so on.The changes of these factors may lead to the general increase of PCT in the HFRS patients.Therefore,the comprehensive consideration of multiple influencing factors can help to better identify the presence of bacterial infection,and thus avoid the overuse of antibiotics in the HFRS patients.