藤茶及二氢杨梅素的生物学功能研究进展

Progress of Biological Functions of Vine Tea and Dihydromyricetin

藤茶(vine tea)为葡萄科(Vitacea)蛇葡萄属(Ampelopsis michx.)显齿蛇葡萄(Ampelopsis grossedentata)植物的嫩茎叶经加工而成的茶制品。藤茶中含有丰富黄酮类物质,其中最主要成分为二氢杨梅素(dihydromyricetin,DMY)。科学研究发现,藤茶及其主要活性成分具有抗癌、抗氧化、降脂、抗炎、抑菌和抗疲劳等作用,并且向一些重要基因和调控信号传导通路,参与不同的生物学功效,但其作用的分子机理尚不清楚。作者根据近年来国内外的最新研究进展,对藤茶及其主要活性成分的生物活性、调控的信号传导通路和作用的关键靶基因等进行了系统综述,以期为藤茶及其活性成分的深入研究提供理论参考,也有利于今后进一步对藤茶及其主要活性成分的开发利用。

Vine tea is classified as an Ampelopsis grossedentata of the Ampelopsis michx.in the the family of Vitacea.Vine tea is rich in flavonoids,among which dihydromyricetin(DMY)is the most important component.Scientific research has found that vine tea and its main bioactive components have various biological effects such as anti-cancer,anti-oxidation,lipid-lowering,anti-inflammation,anti-bacteria and anti-fatigue.Current studies have found that vine tea and its main bioactive components participate in different biological functions via targeting some important genes and regulating signal transduction pathways.However,the molecular mechanism of its effects is still unclear.In this paper,the biological activities,signal transduction pathways and key target genes of vine tea and its main bioactive components were systematically reviewed according to the updated domestic and international progress,expecting to provide theoretical reference for the in-depth study of vine tea and its bioactive components,and to be conducive to the further development and utilization of vine tea and its main bioactive components in the future.