COX-2、VEGF-c及ERK在舌鳞癌中的表达与病理特征、预后的关系

Expressions of COX-2, VEGF-C and ERK in Tongue Squamous Cell Carcinoma and Their Correlations with Pathological Features and Prognosis

目的分析环氧化酶-2(COX-2)、血管内皮生长因子-c(VEGF-c)及胞外信号调节激酶(ERK)在舌鳞癌中的表达与病理特征、预后的关系。方法收集2017年6月—2019年6月收治且经病理确诊的舌鳞癌手术切除标本95例,另选取癌旁正常组织作为对照组。比较2组COX-2、VEGF-c及ERK表达情况及与舌鳞癌临床病理特征的关系。术后对患者随访2年,分析COX-2、VEGF-c及ERK表达对预后的影响。结果舌鳞癌组COX-2、VEGF-c及ERK阳性表达率均高于对照组(P<0.01)。舌鳞癌有淋巴结转移者COX-2、VEGF-c及ERK阳性表达率高于无淋巴结转移者,且病理分期Ⅲ~Ⅳ期者COX-2、VEGF-c阳性表达率高于Ⅰ~Ⅱ期者,中低分化者VEGF-c阳性表达率高于高分化者(P<0.05,P<0.01)。COX-2、VEGF-c及ERK阳性表达者的2年生存率低于COX-2、VEGF-c及ERK阴性表达者(P<0.05)。COX-2、VEGF-c及ERK阳性表达者生存时间短于COX-2、VEGF-c及ERK阴性表达者。肿瘤中低分化、病理分期Ⅲ~Ⅳ期、有淋巴结转移及COX-2、VEGF-c、ERK阳性表达是舌鳞癌患者预后的危险因素(P<0.05,P<0.01)。结论COX-2、VEGF-c及ERK在舌鳞癌中阳性表达与肿瘤病理分期、淋巴结转移、组织分化程度密切相关,可通过检测上述蛋白表达情况对患者预后进行评估。

Objective To analyze expressions of cyclooxygenase-2(COX-2),vascular endothelial growth factor-c(VEGF-c),and extracellular signal-regulated kinase(ERK)in tongue squamous cell carcinoma(TSCC)and their correlations with pathological features and prognosis.Methods A total of 95 samples of TSCC surgically resected and pathologically diagnosed from patients who had been admitted between June 2017 and June 2019 were collected,and normal adjacent tissues were selected as control group.Expressions of COX-2,VEGF-c and ERK and correlations with clinicopathological characteristics of TSCC were compared in two groups.The patients were followed up for two years after operation to analyze effects of expressions of COX-2,VEGF-c and ERK on prognoses of patients.Results The positive expression rates of COX-2,VEGF-c and ERK in TSCC were significantly higher than those in control group(P<0.01).The positive expression rates of COX-2,VEGF-c and ERK in TSCC patients with lymph node metastasis were significantly higher than those in patients without lymph node metastasis,and the positive expression rates of COX-2 and VEGF-c in patients with pathological stagesⅢ-Ⅳwere significantly higher than those in patients with stagesⅠ-Ⅱ,and the positive expression rate of VEGF-c in patients with moderate and low differentiation was significantly higher than that in patients with high differentiation(P<0.05,P<0.01).The 2-year survival rate of patients with positive expressions of COX-2,VEGF-c and ERK was significantly lower than that of patients with negative expressions of COX-2,VEGF-c and ERK(P<0.05).The survival time of patients with positive expressions of COX-2,VEGF-c and ERK was significantly shorter than that of patients with negative expressions of COX-2,VEGF-c and ERK.Moderate and low differentiation,pathological stage III-IV,lymph node metastasis and positive expressions of COX-2,VEGF-c and ERK were risk factors affecting prognoses of patients with TSCC(P<0.05,P<0.01).Conclusion The positive expressions of COX-2,VEGF-c and ERK in TSCC are closely related to tumor pathological stage,lymph node metastasis and tissue differentiation,and prognoses of patients can be evaluated by detecting expressions of the above proteins.