以酮症酸中毒为首发症状的小儿糖尿病临床治疗效果研究

Study on the Clinical Treatment Effect of Pediatric Diabetes with Ketoacidosis as the First Symptom

目的分析以酮症酸中毒为首发的小儿糖尿病患儿为研究对象,小剂量胰岛素的治疗效果。方法选择2017年9月—2021年8月该院收治的56例小儿糖尿病患儿为研究对象,首发症状均为酮症酸中毒,双盲法随机分组,观察组28例实施常规治疗+小剂量胰岛素,对照组28例实施常规治疗,对比两组临床疗效、血糖与胰岛素水平、生化指标和并发症。结果观察组疗效(96.43%)高于对照组(64.28%),差异有统计学意义(P<0.05);治疗前,两组餐前血糖与餐后2 h血糖指标对比差异无统计学意义(P>0.05);治疗后,观察组更优,差异有统计学意义(P<0.05);治疗后,观察组胰岛素水平优于对照组,生化指标优于对照组,差异有统计学意义(P<0.05);观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论酮症酸中毒小儿糖尿病患儿实施小剂量胰岛素治疗方案,能够提升降血糖效果,维持生化指标与胰岛素指标稳定,提升疗效,降低并发症的发生,效果显著。

Objective To analyze the therapeutic effect of low-dose insulin in children with diabetes with ketoacidosis as the research object.Methods 56 children with diabetes who were admitted to the hospital from September 2017 to August 2021 were selected as the research objects.The first symptoms were ketoacidosis,and they were randomly grouped by double-blind method.28 cases in the observation group received conventional treatment+low-dose insulin,and 28 cases in the control group received conventional treatment.The clinical efficacy,blood glucose and insulin levels,biochemical indicators and complications were compared between the two groups.Results The curative effect of the observation group(96.43%)was higher than that of the control group(64.28%),and the difference was statistically significant(P<0.05).There was no statistically significant difference in the blood glucose before the intervention and the blood glucose 2 h after the meal between the two groups(P>0.05).The observation group was better after the treatment,and the difference was statistically significant(P<0.05).After treatment,the insulin level of the observation group was better than that of the control group,and the biochemical index was better than that of the control group,the difference was statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion In children with diabetes mellitus with ketoacidosis,a low-dose insulin therapy program is implemented.It can improve the effect of lowering blood glucose,maintain the stability of biochemical indicators and insulin indicators,improve the efficacy,and reduce the occurrence of complications.The effect is significant.