益生菌辅助以左氧氟沙星为基础三联方案治疗对Hp感染胃溃疡疗效比较

Curative Effect of Probiotics-assisted Levofloxacin-based Triple Therapy on Hp Infection and Gastric Ulcer

目的探讨益生菌辅助以左氧氟沙星为基础三联方案在幽门螺杆菌(Hp)感染的应用效果及对根治率和不良药物反应的影响。方法?前瞻性选择2017年2月—2020年10月我院就诊的110例Hp感染胃溃疡患者,根据简单随机法分为观察组和对照组,每组各55例,其中对照组予以左氧氟沙星为基础三联方案治疗,观察组在以上基础联合益生菌。两组均持续治疗两周。记录治疗后Hp根治率,并比较两组临床症状评分、血清炎症因子的变化及不良药物反应发生情况。结果观察组Hp根治率(92.73%)高于对照组(78.18%)(P<0.05);治疗前两组腹胀、腹痛及反酸嗳气临床症状评分、血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)及C反应蛋白(CRP)比较无明显差异(P>0.05),治疗后均显著改善(P<0.05),且观察组改善程度优于对照组(P<0.05);观察组不良药物反应发生率低于对照组,差异有统计学意义(P<0.05)。结论益生菌辅助以左氧氟沙星为基础三联方案治疗用于Hp感染胃溃疡中,不仅能显著改善其临床症状,提高其根治率,还能减轻炎症反应,此外还能减少不良药物反应发生风险,安全性较好。

Objective To investigate the curative effect,radical rate and adverse drug reactions of probiotics-assisted levofloxacin-based triple therapy in the treatment of Helicobacter pylori (Hp) infection.Methods Totally,110 patients with Hp infection and gastric ulcer admitted to the hospital between February 2017 and October 2020 were selected prospectively.They were divided into observation group and control group by simple random method,with 55 cases in each group.The control group was given levofloxacin-based triple therapy,and the observation group was treated with probiotics on this basis.Both groups received 2 weeks of continuous treatment.The Hp radical rate after treatment was recorded,and the clinical symptom scores,changes in serum inflammatory factors and adverse drug reactions were compared between the two groups.Results The Hp radical rate of the observation group (92.73%) was higher than that of the control group (78.18%) (P<0.05).There was no significant difference in the scores of clinical symptoms (abdominal distension,abdominal pain and belching),serum tumor necrosis factor α (TNF-α),interleukin 6 (1L-6) and C-reactive protein (CRP) between the two groups before treatment (P>0.05).After treatment,the above indicators were significantly improved (P<0.05),and the improvement of observation group was better than that of the control group (P<0.05).The incidence of adverse drug reactions in the observation group was lower than that in the control group (P<0.05).Conclusion Probiotics-assisted levofloxacin-based triple therapy for Hp infection and gastric ulcer not only can significantly improve clinical symptoms and the radical rate and reduce inflammation but also reduce the risk of adverse drug reactions,with higher safety.