女性早发冠心病病变程度影响因素分析

Analysis of risk factors associated with the degree of premature coronary heart disease in women

目的分析女性早发冠心病冠脉病变严重程度与冠心病危险因素的关系。方法纳入2017年1月至2020年4月经冠状动脉造影明确冠心病诊断的年龄<65岁的女性患者212例。对患者的冠脉病变进行Gensini评分,根据Gensini评分,将患者分为轻度病变组(n=67)、中度病变组(n=70)和重度病变组(n=75)。对各组间冠心病危险因素进行比较,并分析各危险因素与Gensini评分的关系。结果三组间高密度脂蛋白胆固醇、非高密度脂蛋白胆固醇、载脂蛋白B、血尿酸差异有统计学意义(P<0.05)。多元线性回归分析显示,糖化血红蛋白与尿酸水平与Gensini评分正相关,B值分别为3.571、0.08(P<0.01)。结论糖化血红蛋白及尿酸水平升高可能加重女性早发冠心病患者冠脉病变严重程度。

Objective To analyze the relationship between the severity of coronary artery disease and risk factors related to coronary heart disease (CHD) in women with premature CHD.Methods A total of 212 female patients with premature CHD aged<65 years confirmed by coronary angiography from January 2017 to April 2020 were included.The coronary lesions of the patients were evaluated by Gensini score.According to the score,the patients were divided into mild lesion group (n=67),moderate lesion group (n=70),and severe lesion group (n=75).The risk factors among each group were compared,and the relationship between the risk factors and Gensini score was analyzed.Results There were significant differences in high-density lipoprotein cholesterol(HDL-C),non-HDL-C,apolipoprotein B,and blood uric acid among 3 groups (P<0.05).Multiple linear regression analysis showed that Hb A;c and uric acid levels had positive impacts on Ginsini score,with B values of 3.571 and 0.08 (P<0.01).Conclusions The levels of HbA;c and uric acid have positive impacts on the degree of coronary lesions in women with premature CHD.