妊娠期单纯低甲状腺素血症的危险因素和对母婴结局的影响

Risk Factors of Gestational Isolated Hypothyroxinemia and Its Effect on Maternal and Infant Outcomes

妊娠期单纯低甲状腺素血症又称妊娠期低甲状腺素(thyroxine,T_(4))血症,是指妊娠妇女甲状腺自身抗体阴性、血清促甲状腺激素(thyroid stimulating hormone,TSH)水平正常但血清游离甲状腺素(free thyroxine,FT_(4))水平低于妊娠期特异性参考范围下限。目前,妊娠期低T_(4)血症的病因尚不明确,是否会增加妊娠期糖尿病(gestational diabetes mellitus,GDM)、妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)和早产等不良妊娠结局的发生风险以及是否影响子代智力及神经系统发育尚存争议。对妊娠期低T_(4)血症孕妇及其子代开展多中心的研究以及更长时间的追访是解决争议的方法之一。

Gestational isolated hypothyroxinemia,also known as gestational hypothyroxinemia,refers to pregnant women with negative thyroid autoantibodies,normal thyroid stimulating hormone(TSH)level but lower free thyroxine(FT_(4))level than the lower limit of specific reference range during pregnancy.At present,the etiology of gestational isolated hypothyroxinemia is unclear.Whether it will increase the risk of gestational diabetes mellitus(GDM),hypertensive disorders of pregnancy(HDP),preterm birth and other adverse outcomes of pregnancy remains controversial.Whether gestational isolated hypothyroxinemia affects the intelligence and nervous system development of offspring is still controversial.Therefore,one of the methods to solve the dispute is to carry out a multicenter research and longer follow-up visit to pregnant women with gestational isolated hypothyroxinemia and their offspring.