乳腺癌化疗相关认知损害神经影像标志物的研究进展

Research progress on neuroimaging biomarkers of chemotherapy-related cognitive impairment in breast cancer

神经影像技术特别是MRI在评估脑解剖结构及功能变化等方面应用广泛,已逐渐成为临床研究乳腺癌化疗相关认知损害(chemotherapy-related cognitive impairment,CRCI)的有力工具,并为其早期诊断提供了客观的影像诊断标志物。本文就神经影像方法在乳腺癌CRCI神经影像标志物研究中的应用进展进行文献综述,以期为揭示其病理生理机制及早期诊断研究提供影像学依据。

Neuroimaging technology,especially magnetic resonance imaging(MRI),is widely used in evaluating the alterations of brain anatomy and function,and has gradually become a powerful tool for clinical study of chemotherapy-related cognitive impairment(CRCI)in breast cancer,and provides a possible neuroimaging diagnostic marker for its early diagnosis.The article reviewed the application of neuroimaging in the study of neuroimaging biomarkers of CRCI in breast cancer,in order to provide imaging evidence for revealing its pathophysiological mechanism and early diagnosis.