芪归通络汤联合二甲双胍治疗2型糖尿病疗效观察及对血糖波动的影响

Clinical Observation of Qigui Tongluo Tang Combined with Dimethylbiguanide for Type 2 Diabetes Mellitus and Its Effect on Blood Glucose Fluctuation

目的:观察芪归通络汤联合二甲双胍治疗2型糖尿病临床疗效及对血糖波动的影响。方法:选取2型糖尿病患者150例,按随机数字表法分为对照组和研究组各75例。对照组采用二甲双胍治疗,研究组采用芪归通络汤联合二甲双胍治疗。治疗1个月后,比较2组临床疗效,并对2组治疗前后糖化血红蛋白(HbA1c)、餐后2 h血糖(P2hBG)、空腹血糖(FBG)、血糖波动幅度(MAGE)进行比较。结果:研究组总有效率为92.0%,对照组为72.0%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组HbA1c、FBG、P2hBG水平均较治疗前降低(P<0.05),且研究组HbA1c、FBG、P2hBG水平低于对照组(P<0.05)。治疗后,研究组低血糖发生率为5.3%,对照组为14.7%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组MAGE比较,差异无统计学意义(P>0.05);治疗后,2组MAGE均较治疗前降低(P<0.05),且研究组MAGE低于对照组(P<0.05)。结论:芪归通络汤联合二甲双胍治疗2型糖尿病,能够提高临床疗效,改善血清HbA1c、FBG、P2hBG水平,降低低血糖发生率,稳定血糖波动。

Objective:To observe the clinical effect of Qigui Tongluo tang combined with dimethylbiguanide for type 2 diabetes mellitus and its effect on blood glucose fluctuation.Methods:A total of 150 cases of patients with type 2 diabetes mellitus were selected and divided into the control group and the study group according to the random number table method,with 75 cases in each group.The control group was treated with dimethylbiguanide,and the study group was treated with Qigui Tongluo tang combined with dimethylbiguanide.After one month of treatment,the clinical effects in the two groups were compared.Before and after treatment,glycosylated hemoglobin A1 c(HbA1 c),2-hour postprandial blood glucose(P2 hBG),fasting blood glucose(FBG)and mean amplitude of glycemic excursions(MAGE)in the two groups were compared.Results:The total effective rate was 92.0%in the study group and 72.0%in the control group,the difference being significant(P<0.05).After treatment,The levels of HbA1 c,FBG and P2 hBG in the two groups were decreased when compared with that before treatment(P<0.05),and the levels of HbA1 c,FBG and P2 hBG in the study group were lower than those in the control group(P<0.05).The incidence of hypoglycemia was 5.3%in the study group and 14.7%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of MAGE between the two groups(P>0.05).After treatment,MAGE in the two groups was decreased when compared with that before treatment(P<0.05),and the MAGE in the study group was lower than that in the control group(P<0.05).Conclusion:The therapy of Qigui Tongluo tang combined with dimethylbiguanide for type 2 diabetes mellitus can improve the clinical effect,the levels of HbA1 c,FBG and P2 hBG in serum and blood glucose fluctuation,as well as reduce the incidence of hypoglycemia.