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补肾壮骨汤辅助治疗骨质疏松性椎体压缩性骨折肝肾不足证临床研究 被引量:2

Clinical Study on Bushen Zhuanggu Tang for Osteoporotic Vertebral Compression Fracture with Liver and Kidney Deficiency Syndrome
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摘要 目的:观察补肾壮骨汤辅助治疗骨质疏松性椎体压缩性骨折(OVCF)肝肾不足证的临床疗效。方法:选取104例OVCF肝肾不足证患者,按区组随机化分组法分为手术组和联合组,每组52例。手术组给予经皮穿刺椎体成形术(PVP)治疗,术后进行抗感染、抗骨质疏松和康复锻炼治疗,联合组在手术组基础上给予补肾壮骨汤治疗。比较2组治疗前后Cobb角、Oswestry功能障碍指数(ODI)、L_(1-4)骨密度(BMD)及视觉模拟评分法(VAS)评分;比较2组临床疗效、骨折再发生率及不良反应。结果:治疗后,2组Cobb角均较治疗前减小,ODI评分均较治疗前降低,L_(1-4)BMD均较治疗前增大,差异均有统计学意义(P<0.05);联合组Cobb角小于手术组,ODI评分低于手术组,L_(1-4)BMD大于手术组,差异均有统计学意义(P<0.05)。治疗1个月、2个月、3个月,2组VAS评分均较治疗前降低,联合组VAS评分低于治疗后同期手术组,差异均有统计学意义(P<0.05)。联合组总有效率为96.15%,高于手术组的82.69%(P<0.05)。手术组邻近椎体骨折再发生率为5.77%,联合组邻近椎体骨折再发生率为1.92%,2组比较,差异无统计学意义(P>0.05)。2组均未出现与药物相关的不良反应。结论:补肾壮骨汤辅助治疗OVCF肝肾不足证,可缓解患者脊柱侧弯和腰脊疼痛症状,增加椎体BMD,改善椎体功能,安全性高。 Objective:To observe the clinical effect of Bushen Zhuanggu tang for osteoporotic vertebral compression fracture(OVCF)with liver and kidney deficiency syndrome.Methods:A total of 104 cases of OVCF patients with liver and kidney deficiency syndrome were divided into the operation group and the combination group according to the block randomized grouping method,with 52 cases in each group.After percutaneous vertebroplasty(PVP),the operation group was given treatment for anti-infection,anti-osteoporosis and rehabilitative exercise,and the combination group was additionally treated with Bushen Zhuanggu tang based on the treatment of the operation group.Before and after treatment,the Cobb angle,Oswestry Disability Index(ODI),L_(1-4) bone mineral density(BMD)and Visual Analogue Scale(VAS)scores in the two groups were compared.The clinical effects,the incidence of refracture and the adverse reactions in the two groups were compared.Results:After treatment,the Cobb angles and ODI scores in the two groups were decreased when compared with those before treatment,and the L_(1-4) BMD were increased,differences being significant(P<0.05).The Cobb angle in the combination group was smaller than that in the operation group,the ODI score was lower,and L_(1-4) BMD was larger,differences being significant(P<0.05).After one,two and three months of treatment,the VAS scores in the two groups were decreased when compared with those before treatment,and the VAS score in the combination group was lower than that in the operation group at the same period,differences being significant(P<0.05).The total effective rate was96.15%in the combination group,higher than that of 82.69%in the operation group(P<0.05).The incidence of refracture of adjacent vertebral body was 5.77%in the operation group and 1.92%in the combination group,there being no significance in the difference(P>0.05).There was no adverse reactions related to drugs in the two groups.Conclusion:Bushen Zhuanggu tang for OVCF with liver and kidney deficiency syndrome can relieve symptoms of vertebral scoliosis and pain in lumbar vertebra,increase vertebrae BMD and improve vertebral function,with high safety.
作者 林清南 LIN Qingnan
出处 《新中医》 CAS 2022年第2期86-89,共4页 New Chinese Medicine
关键词 骨质疏松性椎体压缩性骨折 肝肾不足证 经皮穿刺椎体成形术 补肾壮骨汤 COBB角 OSWESTRY功能障碍指数 骨密度 疼痛 Osteoporotic vertebral compression fracture Liver and kidney deficiency syndrome Percutaneous vertebroplasty Bushen Zhuanggu tang Cobb angle Oswestry Disability Index Bone mineral density Pain
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