影响汗腺发育的信号通路及其参与汗腺样细胞体外重建的研究进展

Research advances on signaling pathways affecting sweat gland development and their involvement in the reconstitution of sweat adenoid cells in vitro

大面积深度烧伤患者因汗腺毁损导致体温调节功能基本丧失,生活质量受到严重影响。目前对于修复汗腺功能的研究较多,然而人体汗腺发育的机制尚未完全阐明。越来越多的研究表明Wnt/β连环蛋白、外胚叶发育不全/外胚叶发育不全受体/核因子κB、音猬因子、叉头框转录因子等信号通路彼此级联共同影响汗腺发育,并且已有研究报道可以利用级联信号通路实现汗腺样细胞的体外重建。现就影响汗腺发育的信号通路及其参与汗腺样细胞的体外重建情况作一综述。

The damage of sweat glands in patients with extensive deep burns results in the loss of thermoregulation,which seriously affects the quality of life of patients.At present,there are many researches on the repair of sweat gland function,but the mechanism of human sweat gland development has not been fully clarified.More and more studies have shown that the cascaded pathways of Wnt/β-catenin,ecto-dysplasin A/ectodysplasin A receptor/nuclear factor-κB,sonic hedgehog,and forkhead box transcription factor jointly affect the development of sweat glands,and it has been reported that the cascaded signaling pathways can be used to achieve the reconstruction of sweat adenoid cells in vitro.This article reviews the signaling pathways that affect the development of sweat glands and their involvement in the reconstruction of sweat adenoid cells in vitro.