长链非编码RNA在变应性鼻炎中的生物学机制研究进展

Research progress on biological mechanism of long non-coding RNA in allergic rhinitis

长链非编码RNA(lncRNA)起初被认为是不具蛋白质编码功能的非编码RNA,随着检测技术的更新迭代,人们对其来源、分类、功能的认识逐渐深入,尤其在免疫调节方面,发现lncRNA起到关键的调节作用。变应性鼻炎(AR)为免疫调节失衡所产生的疾病,研究发现lncRNA与AR的发生发展密切相关。目前的研究以AR相关lncRNA表达谱差异分析和特异性lncRNA的生物学功能两大类为主,故本文从这两个方面对近年来的研究进行总结,使我们更好地认识lncRNA在AR生物学机制中的影响,也为AR的诊断及治疗提供新的思路。

Long non-coding RNA(lncRNA)was initially considered as a non-coding RNA without protein-coding function.With the update and iteration of sequencing technology,people have gradually deepened their understanding of its source,classification and function.Especially in the regulation of immunity,lncRNA was found to play a key role of regulatory.It is believed that allergic rhinitis(AR)is caused by imbalance of immune regulation.Studies have found that lncRNA is closely related to the occurrence and development of AR.The current research focuses on the differential analysis of AR-related lncRNA expression profiles and the biological functions of specific lncRNA.Therefore,this paper summarizes recent studies of lncRNA and AR.This will enable us to better understand the impact of lncRNA on the biological mechanism of AR.It also provides new ideas for the diagnosis and treatment of AR.