天津市成人夜间睡眠时长与血脂水平的关系

Associations of night sleep duration with blood lipid levels of adults in Tianjin

目的探索天津市成年人夜间睡眠时长与TC、TG、HDL-C和LDL-C水平之间的关系。方法本研究分析了"十三五"国家重点研发计划"京津冀地区自然人群队列研究"的部分基线数据。采用多阶段分层整群抽样的方法,选取2018年1月8日-2020年1月9日在天津市两家医院体检中心进行体检的498个单位的员工作为研究对象。采用问卷调查收集人口学特征、现病史、生活方式等信息。用简化的匹兹堡睡眠量表(pittsburgh sleep quality index, PSQI)评估研究对象的睡眠状况;并测量调查对象的身高、体重和空腹静脉血中TC、TG、HDL-C和LDL-C浓度。进行多重线性相关和曲线性(U型)相关分析研究睡眠时长与血脂水平的关系。结果共17 807例成人纳入分析,男性占比51.74%,年龄为44(35, 57)岁。在完全调整混杂因素后,睡眠时长与TC(β=-0.027,P<0.001)、LDL-C(β=-0.039,P<0.001)和BMI(β=-0.167,P<0.001)呈线性负相关;与LDL-C呈U型相关(β_(一次项)=-0.202,P<0.001;β_(二次项)=0.011,P=0.004);未发现睡眠时长与TG和HDL-C水平之间存在相关性。结论短睡眠与TC和BMI升高的风险相关,而过短和过长的睡眠时间都与LDL-C升高的风险相关,提示合理的睡眠时长对于维持正常的血脂水平具有重要意义。

Objective We aim to assess the associations between night sleep duration and TC, TG, HDL-C and LDL-C among adults who have not been diagnosed with hyperlipidemia. Methods Using a multi-stage stratified cluster sampling method, employees from 498 units who underwent physical examinations at one of two hospitals in Tianjin from January 8, 2018 to January 9, 2020 were selected as the study population. Demographic characteristics, disease history, lifestyle and other information were collected by questionnaire. The simplified Pittsburgh Sleep Quality Index(PSQI) was used to assess sleep duration. Fasting TC, TG, HDL-C, LDL-C, and height and weight were measured. Independent associations of night sleep duration with TC, TG, HDL-C, LDL-C, and BMI were evaluated with multiple U-shaped or linear regression models. Results A total of 17 807 participants with a median of 44 years completed the investigation. Sleep duration negatively associated with TC(β=-0.027, P<0.001), LDL-C(β=-0.039, P<0.001) and BMI(β=-0.167, P<0.001) and U-shaped associated with LDL-C(β_(linear term)=-0.202, P<0.001;β_(quadratic term)=0.011, P=0.004). No associations were found between sleep duration and TG or HDL-C. Conclusion Night sleep duration was associated with TC, HDL-C and BMI, suggesting optimal sleep duration plays an important role in maintaining lipid homeostasis.