逍遥散合二至丸加减治疗肝郁型迟发型痤疮的临床疗效研究

Clinical Study on the Therapeutic Effect of Xiaoyao Powder Plus Erzhi Pills for Delayed Acne of Liver Depression Type

【目的】研究逍遥散合二至丸加减治疗肝郁型迟发型痤疮的临床疗效。【方法】将48例肝郁型迟发型痤疮患者随机分为试验组和对照组,每组各24例。试验组给予口服逍遥散合二至丸加减治疗,对照组给予口服丹参酮胶囊治疗,2周为1个疗程,共治疗4个疗程并随访2个月。观察2组患者治疗前后痤疮综合分级系统(GAGS)评分、中医证候量化评分的变化情况,并评价2组患者的临床综合疗效、安全性和复发情况。【结果】(1)治疗4个疗程(8周)后,试验组和对照组的综合疗效愈显率分别为66.67%(16/24)、37.50%(9/24),组间比较,试验组的临床综合疗效明显优于对照组(P<0.01)。(2)治疗后,2组患者的GAGS评分和中医证候量化评分均较治疗前明显降低(P<0.01),且试验组的降低作用均明显优于对照组,差异均有统计学意义(P<0.01)。(3)随访2个月,试验组的复发率为8.33%(2/24),明显低于对照组的31.58%(6/19),差异有统计学意义(P<0.01)。(4)治疗期间,试验组和对照组均未出现明显的不良反应,均无脱落病例。【结论】逍遥散合二至丸加减治疗肝郁型迟发型痤疮疗效确切,无明显不良反应,复发率低,且能明显改善患者生活质量。

Objective To investigate the clinical efficacy of Xiaoyao Powder plus Erzhi Pills in the treatment of delayed acne of liver depression. Methods A total of 48 patients with delayed acne of liver depression type were randomly divided into trial group and control group,24 cases in each group. The trial group was given oral use of the modified prescription of Xiaoyao Powder plus Erzhi Pills, and the control group was given oral use of Tanshinone Capsules. Two weeks constituted one course of treatment,and the two groups were treated for 4 courses and then were followed up for two months. Before and after treatment,the global acne grading system(GAGS)scores,traditional Chinese medicine(TCM)syndrome quantitative scores of the two groups were compared,and the clinically comprehensive curative effect,safety and recurrence of the two groups were also evaluated. Results(1)After 4 courses of treatment(8 weeks),the markedly effective rate of the clinically comprehensive curative effect in the trial group was 66.67%(16/24),and that of the control group was 37.50%(9/24). The intergroup comparison showed that the trial group had stronger comprehensive curative effect than the control group(P<0.01).(2)After treatment, the GAGS scores and TCM syndrome quantitative scores of the two groups were obviously decreased in comparison with those before treatment(P<0.01),and the effect on decreasing the scores in the trial group was superior to that in the control group,the difference being statistically significant(P<0.01).(3)The results of two-month follow-up showed that the recurrence rate in the trial group was 8.33%(2/24),obviously lower than that in the control group [31.58%(6/19)],and difference being statistically significant(P<0.01).(4)During the course of treatment,no obvious adverse reaction was found in the two groups,none case fell off,either. Conclusion Xiaoyao Powder plus Erzhi Pills exerts certain effect in the treatment of delayed acne of liver depression without obvious adverse reaction and with low recurrence rate. And the combined therapy is effective on significantly improving the quality of life of the patients.