颈性眩晕患者血清Hcy、TNF-α及ET-1表达及意义

Expression and significance of serum Hcy,TNF-αand ET-1 in patients with cervical vertigo

目的探讨颈性眩晕患者血清同型半胱氨酸(Hcy)、肿瘤坏死因子-α(TNF-α)及内皮素-1(ET-1)表达及其与眩晕程度的相关性。方法选取2018年1月至2021年1月海南省干部疗养院收治的颈性眩晕患者162例为眩晕组,健康体检者80例为对照组。检测两组血清Hcy、TNF-α及ET-1水平,Logistic回归分析颈性眩晕发生的相关因素,观察血清Hcy、TNF-α及ET-1表达与眩晕严重程度的关系。结果眩晕组血清Hcy、TNF-α及ET-1水平明显高于对照组(P<0.05);Logistic回归分析显示血清Hcy、TNF-α及ET-1高表达是导致颈性眩晕的危险因素(P<0.05)。随着眩晕程度的加重,患者血清Hcy、TNF-α及ET-1水平呈逐渐升高趋势(P<0.05);眩晕组患者血清Hcy、TNF-α、ET-1水平与眩晕残障评估表(DHI)评分呈显著正相关(P<0.05)。结论颈性眩晕患者血清中Hcy、TNF-α及ET-1高表达,其水平与眩晕程度密切相关。

Objective To investigate the expression of serum homocysteine(Hcy),tumor necrosis factor-α(TNF-α)and endothelin-1(ET-1)in patients with cervical vertigo and their correlation with vertigo degree.Methods A total of 162 patients with cervical vertigo admitted to our hospital from January 2018 to January 2021 were selected as vertigo group and 80 healthy subjects as the control group.The levels of serum Hcy,TNF-αand ET-1 in the two groups were detected.Logistic regression was used to analyze the related factors of cervical vertigo.The relationship between serum Hcy,TNF-αand ET-1 expression and vertigo severity were observed.Results The levels of Hcy,TNF-αand ET-1 in vertigo group were significantly higher than those in control group(P<0.05).Logistic regression analysis showed that the high expression of Hcy,TNF-αand ET-1 in serum was a risk factor for cervical vertigo(P<0.05).With the aggravation of vertigo,serum Hcy,TNF-αand ET-1 levels showed a gradually increasing trend(P<0.05).The levels of Hcy,TNF-αand ET-1 in patients with vertigo group were significantly positively correlated with DHI score(P<0.05).Conclusion The Hcy,TNF-αand ET-1 are highly expressed in serum of patients with cervical vertigo,and their levels are closely related to vertigo degree.