血清降钙素原用于急性左心力衰竭并发肺部感染的早期诊断价值

The Value of Serum Procalcitonin in the Early Diagnosis of Acute Left Heart Failure Complicated with Pulmonary Infection

目的探讨血清降钙素原(procalcitonin,PCT)在急性左心力衰竭并发肺部感染患者早期诊断中的应用价值。方法选取该院在2020年1—12月收治的70例急性左心衰患者作为研究对象,根据是否并发肺部感染,将其分成观察组(感染组,n=35)与对照组(非感染组,n=35),收集其入院后第1、3天血清PCT浓度数据,根据其诊断情况实施计算,分析PCT、C-反应蛋白(C-reactive protein,CRP)的诊断意义,绘制接受者操作特征曲线(receiver operating characteristic curve,ROC),对PCT诊断界值进行评估。结果观察组患者入院第1天血清PCT表达为(2.44±0.43)ng/mL,第3天为(1.24±0.18)ng/mL,对照组患者入院第1天血清PCT表达为(0.53±0.03)ng/mL,第3天为(0.42±0.03)ng/mL,观察组入院第1天、第3天血清PCT表达均高于对照组,差异有统计学意义(P<0.05)。结论血清PCT在急性左心衰并发肺部感染早期诊断中,敏感性、特异性较高,最佳界值是0.49 ng/mL。

Objective To explore the application value of serum procalcitonin(PCT) in the early diagnosis of patients with acute left heart failure complicated by pulmonary infection. Methods A total of 70 patients with acute left heart failure admitted to the hospital from January to December 2020 were selected as the research objects. According to whether they were combined with lung infection, they were divided into observation group(infected group, n=35) and control group(non-infected group, n=35). The serum PCT concentration data were collected on the 1st and 3rd day after admission. Perform calculations based on the diagnosis, analyze the diagnostic significance of PCT and C-reactive protein(C-reactive protein, CRP), draw the receiver operating characteristic curve(ROC), and evaluate the PCT diagnostic threshold. Results The serum PCT expression of patients in the observation group was(2.44±0.43) ng/mL on the first day of admission, and(1.24±0.18) ng/mL on the third day. The expression of serum PCT in the control group was(0.53±0.03) ng/mL on the first day of admission, and(0.42±0.03) ng/mL on the third day. The expression of serum PCT in the observation group was higher than that in the control group on the 1st and 3rd day of admission, and the difference was statistically significant(P<0.05). Conclusion Serum PCT has high sensitivity and specificity in the early diagnosis of acute left heart failure complicated with pulmonary infection, and the best cut-off value is 0.49 ng/mL.