改良悬浮液肌内注射法对醋酸奥曲肽微球注射效果的影响

Effect of modified suspension intramuscular injection on the effect of octreotide Acetate Microsphere injection

目的分析改良悬浮液肌内注射法对醋酸奥曲肽微球注射效果的影响,为临床用药提供参考依据。方法选取中国医学科学院北京协和医院神经外科接收的79例患者为研究对象,以随机数字表法将其分为两组,传统组39例(醋酸奥曲肽微球注射196次)、改良组40例(醋酸奥曲肽微球注射201次)。传统组参考药品说明书、按常规方法给药,改良组采取改良后的配置方法及注射程序,比较两组注射成功率、患者皮肤硬结情况及疼痛发生情况。结果改良组注射成功率、硬结发生率低于传统组,差异有高度统计学意义(P<0.01);两组疼痛程度评分比较,差异无统计学意义(P>0.05)。结论改良悬浮液肌内注射法可有效改善醋酸奥曲肽微球注射效果。

Objective To analyze the effect of modified suspension intramuscular injection on the effect of Octreotide Acetate Microsphere injection,and to provide a reference for clinical medication.Methods A total of 79 patients from the Department of Neurosurgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences were selected as the research objects.They were divided into two groups by random number table method,a total of 39 cases in the traditional group(196 injections of Octreotide Acetate Microspheres)and a total of 40 cases in the modified group(201 injections of Octreotide Acetate Microspheres).The traditional group referred to the drug instructions and administerd according to the conventional method,while the modified group adopted the improved configuration method and injection procedure.The injection success rate,the patient’s skin induration and the occurrence of pain between the two groups were compared.Results The injection success rate and the incidence of induration in the modified group were lower than those in the traditional group,and the differences were highly statistically significant(P<0.01);there was no statistically significant difference in the pain degree scores between the two groups(P>0.05).Conclusion The modified suspension intramuscular injection method can effectively improve the injection effect of Octreotide Acetate Microspheres.