垂体细胞瘤1例并文献复习

Pituicytoma:report of one case and review of literature

目的探讨垂体细胞瘤的临床病理学特征。方法对1例垂体细胞瘤进行临床病理分析,并复习相关文献。结果患者男性,46岁,临床表现为双眼视力下降,头颅MRI示鞍区占位,大体表现为实性肿瘤,镜下肿瘤由双极梭形细胞构成,呈束状、席纹状或旋涡状排列,肿瘤细胞Vimentin、S⁃100强阳性,GFAP局灶片状阳性,TTF⁃1阳性,垂体激素、Syn、CgA、NF、Galectin⁃3、EMA、CD68、PR、Olig⁃2阴性。结论垂体细胞瘤是鞍区的罕见肿瘤,属于WHOⅠ级,需要与垂体梭形细胞嗜酸细胞瘤、神经垂体颗粒细胞瘤、垂体腺瘤、脑膜瘤等相鉴别。

Objective To discuss the clinicopathological characteristics of the pituicytoma.Methods A case of pituicytoma was analyzed with its clinicopathological characteristics,and the related literature was reviewed.Results The patient was a 46⁃year⁃old male with a clinical manifestation of decreased binocular vision.Head MRI showed the saddle area occupancy.On gross examination,the tumor was solid.Microscopically,the tumor was composed of bipolar elongated spindle cells arranged in fascicles,storiform or swirly pattern.Tumor cells were positive for vimentin,S⁃100 and TTF⁃1,focal positive for GFAP,negative for pituitary hormone,Syn,CgA,NF,galectin⁃3,EMA,CD68,PR and Olig⁃2.Conclusion Pituicytoma is a rare tumor in the sellar region,belonging to WHO gradeⅠ.It needs to be differentiated from spindle cell oncocytomas of the pituitary gland,granular cell tumor of the neurohypophysis,pituitary adenoma,meningioma,and so on.