血清miR-92a-1-5p及miR-92a-2-5p表达水平与老年卒中后抑郁的关系

Correlation of serum miR-92a-1-5p and miR-92a-2-5p expression with post-stroke depression in elderly patients

目的分析血清微小核糖核酸-92a-1-5p(miR-92a-1-5p)、miR-92a-2-5p表达水平与老年卒中后抑郁的关系。方法选取2018年2月至2020年10月胶州中心医院收治的129例老年卒中患者为研究组,另选取110名同期健康体检者为对照组,均检测血清miR-92a-1-5p、miR-92a-2-5p表达。采用汉密尔顿抑郁量表评估研究组入院后1个月内合并抑郁情况。采用SPSS 23.0统计软件进行数据分析。根据数据类型,分别采用单因素方差分析或χ^(2)检验进行组间比较。采用logistic回归分析法分析老年卒中患者合并抑郁的影响因素。结果研究组患者血清miR-92a-1-5p、miR-92a-2-5p表达水平均高于对照组(P<0.05)。研究组患者入院1个月后合并抑郁患者(抑郁组)占比为37.98%(49/129),其血清miR-92a-1-5p、miR-92a-2-5p表达水平均高于未合并抑郁患者(非抑郁组)(P<0.05)。女性、美国国立卫生研究院卒中量表评分、基底节病变、左额病变、文化程度为高中以上、家庭支持度降低、血清miR-92a-1-5p和miR-92a-2-5p表达升高均为老年卒中后抑郁的危险因素(P<0.05)。结论老年卒中患者血清miR-92a-1-5p和miR-92a-2-5p表达高,且可增加老年卒中后抑郁风险。

Objective To analyze the correlation of expression levels of serum micro-ribonucleic acid-92a-1-5p(miR-92a-1-5p)and miR-92a-2-5p with post-stroke depression in elderly patients.Methods A total of 129 elderly stroke patients admitted in our hospital from February 2018 to October 2020 were selected as the study group,and another 110 healthy subjects who took physical examination at the same period were recruited as control group.The expression of serum miR-92a-1-5p and miR-92a-2-5p of all the subjects were detected with quantitative real-time polymerase chain reaction.Hamilton depression scale-17 was used to evaluate the depression in the study group within 1 month after admission.SPSS statistics 23.0 was used for data analysis.According to the data type,one-way analysis of variance or Chi-square test was employed for comparison between groups.Logistic regression analysis was adopted to analyze the influencing factors of depression in elderly stroke patients.Results The expression levels of miR-92a-1-5p and miR-92a-2-5p were significantly higher in the study group than the control group(P<0.05).In the study group,37.98%(49/129)patients were complicated with depression in 1 month after admission.And the depressive patients had obviously higher levels of the two molecules than those without depression(P<0.05).Female,National Institutes of Health stroke scale score,basal ganglia lesions,left frontal lobe lesions,education level above high-middle school,decreased family support,and elevated serum levels of miR-92a-1-5p and miR-92a-2-5p were risk factors of post-stroke depression in elderly patients(P<0.05).Conclusion Higher expression levels of serum miR-92a-1-5p and miR-92a-2-5p indicate increased risk for depression in elderly stroke patients.