2型糖尿病与肠道菌群关系的研究进展

Research progress of relationship between type 2 diabetes mellitus and intestinal flora

糖尿病是全球最大的健康问题之一,有较高的残疾率和死亡率,致使国家的医疗成本增加,患者的经济负担加重。在过去的十年中,许多研究表明肠道菌群的改变与包括糖尿病在内的多种全身性疾病之间存在关联。众所周知,生活方式、脂肪和高糖食物摄入的增加以及宿主基因等因素都可能导致2型糖尿病(T2DM)。最近的一些研究表明,肠道菌群组成的变化可以引发T2DM。本文对T2DM与肠道菌群相关性的研究现状进行了综述。

Diabetes is one of the biggest health problems in the world,and has quite high incidences of disability and mortality,which increase the cost of health care to countries and financial burden on patients.In the past decade,many studies have shown that there is an association between changes in the intestinal flora and various systemic diseases,including diabetes.It is well known that factors such as lifestyle,increased intake of fat and high-sugar foods,and host genes may all contribute to type 2 diabetes mellitus(T2DM).Some recent studies have shown that changes in the composition of intestinal flora can trigger T2DM.In this paper,we reviewed the current research status of the correlation between T2DM and intestinal flora.