主观认知下降非药物干预研究进展

Research progress in non-pharmacologic interventions in subjective cognitive decline

主流观点认为主观认知下降(SCD)是阿尔茨海默病(AD)的临床前长达10余年的隐匿性阶段,其客观神经心理学功能处于正常范围,但脑内病理改变已经出现,在近年来被视为预测及早期干预AD的关键时期。由于在SCD阶段进行药物干预并不适用,因此积极探索非药物干预途径成为目前研究的主要方向。本文旨在总结评价SCD国内外非药物干预最新研究进展,以期为临床提供防治AD的有效策略。

The mainstream holds subjective cognitive decline(SCD)as more than ten-year latent preclinical stage of Alzheimer′s disease(AD).Due to its normal objective neuropsychological function and the presence of pathological changes in the brain,SCD has been regarded as a key period for the prediction and early intervention of Alzheimer′s disease in recent years.Since pharmacologic interventions in the SCD stage is not applicable,active non-pharmacologic interventions and effective prevention have become the main orientation of the current research.This paper aims to summarize and evaluate the latest research progress of non-pharmacologic interventions in SCD both in China and in other countries to provide effective strategies for AD prevention and treatment clinically.