摘要
脑啡肽酶(NEP)是一种普遍存在的金属肽酶,可以水解体内多种肽类物质。目前研究证明,NEP可以通过调节利钠肽系统、肾素-血管紧张素-醛固酮系统和激肽-激肽释放酶系统等影响心力衰竭进展,血管紧张素受体脑啡肽酶抑制剂在临床应用的益处也得到证实,因此NEP可以作为治疗心力衰竭的新靶点。然而也正因为NEP作用的广泛性,引发了人们对其在心力衰竭患者临床治疗安全性方面的普遍关注。
Neprilysin(NEP)is a ubiquitous metallopeptidase that can hydrolyze a variety of peptides in the body.Current studies have shown that NEP can affect the progression of heart failure by regulating the natriuretic peptide system,renin-angiotensin-aldosterone system,and kinin-kallikrein system,etc.Because the benefits of angiotensin receptor neprilysin inhibitor has also been confirmed in clinical applications,NEP can be used as a new target for the treatment of heart failure.However,because of the wide application of NEP′s effects,it has aroused widespread concern about its safety in the clinical treatment of heart failure.
作者
赵玲
马丹
刘凤歧
ZHAO Ling;MA Dan;LIU Feng-Qi(Department of Critical Care Medicine, the First Hospital of Harbin Medical University, Harbin 150001, China)
出处
《中华老年多器官疾病杂志》
2022年第1期63-66,共4页
Chinese Journal of Multiple Organ Diseases in the Elderly
基金
黑龙江省自然科学基金面上项目(H201446)。
关键词
心力衰竭
脑啡肽酶
利钠肽
交感神经的过度激活
血管紧张素受体脑啡肽酶抑制剂
认知功能
heart failure
neprilysin
natriuretic peptide
excessive activation of sympathetic nerves
angiotensin receptor neprilysin inhibitor
cognitive function
