动脉粥样硬化性疾病与肿瘤发生的相关性及机制研究进展

Research progress of correlation and underlying mechanisms between atherosclerotic disease and cancer

动脉粥样硬化性疾病和肿瘤严重威胁人类健康。临床研究显示,动脉粥样硬化性疾病和肿瘤的发生显著相关,动脉粥样硬化患者中肿瘤的发生率高于非动脉粥样硬化者,同时,肿瘤人群中动脉粥样硬化性疾病的发生率亦显著高于非肿瘤人群。动脉粥样硬化性疾病和肿瘤看似是两个独立的疾病,但是在发病机制上存在不同水平的关联,二者不仅存在共同的危险因素,亦存在相关的分子机制。基于动脉粥样硬化性疾病和肿瘤这两种疾病对人类健康的重要意义,二者间的相关性及其机制日益引起人们的重视。

Atherosclerotic diseases and cancer pose a serious threat to human health.Clinical studies have shown that atherosclerotic diseases are significantly correlated with the pathogenesis of cancer.Patients with atherosclerosis have a higher probability of developing cancer than those without,and the cancer population has a remarkably higher probability of developing atherosclerotic diseases when compared with the non-cancer population.Atherosclerotic diseases and cancer seem to be two independent diseases,but there are certain association in their pathogenesis.The two not only have common risk factors,but also have related molecular mechanisms.Because of the importance of the two diseases to human health,the correlations between them and their mechanisms have attracted increasing attention.