摘要
白藜芦醇是一种天然非黄酮类多酚化合物,具有抗炎、抗自由基、抗心血管疾病、抗肿瘤等诸多药理活性。但因其水溶性差和见光易分解的性质导致其生物利用度低,限制了在食品和药品方面的应用。纳米传递系统因其具有良好的生物相容性、靶向性及缓释性等诸多优点成为极具发展潜力的新型传递系统。基于近年来白藜芦醇纳米传递系统的研究不断深入,对白藜芦醇的主要药理作用、药动学性质及其纳米传递系统的研究进展进行综述,以期为白藜芦醇今后的研究与应用提供参考。
Resveratrol is a natural non-flavonoid polyphenol compound with many pharmacological activities such as antiinflammatory, anti-free radical, anti-cardiovascular and anti-tumor activities. However, due to its poor water solubility and easy decomposition under light, the bioavailability of resveratrol is low, which limits its application in foods and medicines.The nanodelivery system is a new delivery system with great development potential due to its many advantages such as good biocompatibility, targeting and slow release. Intensive research has been made on resveratrol nanodelivery systems in recent years. Hence, this article reviews the main pharmacological effects and pharmacokinetic properties of resveratrol as well as recent progress in resveratrol nanodelivery systems. Through this review, we hope to provide a reference for the future research and application of resveratrol.
作者
张文君
吴梦婷
张国锋
李想
陈泳霖
杨硕
ZHANG Wenjun;WU Mengting;ZHANG Guofeng;LI Xiang;CHEN Yonglin;YANG Shuo(School of Pharmaciutical Science,Harbin University of Commerce,Harbin 150076,China;Heilongjiang Vocational College of Biology Science and Technology,Harbin 150025,China)
出处
《食品科学》
EI
CAS
CSCD
北大核心
2022年第3期371-377,共7页
Food Science
基金
2019年度哈尔滨商业大学“青年创新人才”支持计划项目(2019CX12)。
关键词
白藜芦醇
药理作用
药代动力学
生物利用度
纳米传递系统
resveratrol
pharmacological effects
pharmacokinetics
bioavailability
nanodelivery systems
