摘要
目的探讨肿瘤异常蛋白(TAP)在乳腺癌患者化疗前、后表达情况及其与患者临床特征的关系和临床价值。方法选取2017年6月至2020年10月在南京医科大学第二附属医院确诊为乳腺癌的患者107例。采集其外周末梢血并涂片,检测TAP最大凝聚物面积及乳腺癌患者血清TAP阳性率,分析其不同临床病理特征、化疗前后血清中TAP的相对表达量,评价在乳腺癌中的临床价值。结果乳腺癌患者化疗前TAP阳性表达率72.0%(77/107)高于化疗后的16.8%(18/107),腋窝淋巴结转移的患者TAP阳性表达率84.0%(42/50)高于无淋巴结转移的61.4%(35/57),肿瘤直径大的患者TAP阳性表达率84.5%(49/58)高于肿瘤直径小的患者的57.1%(28/49),Ki-67高表达的患者TAP阳性表达率82.1%(64/78)高于Ki-67低表达的患者的44.8%(13/29),比较差异均有统计学意义(P<0.05)。不同年龄、激素受体水平、人类表达生长因子受体、E-cad、CK5/6、临床分期、远处转移的乳腺癌患者TAP阳性表达率比较,差异均无统计学意义(P>0.05)。化疗前患者的TAP凝聚物面积相对表达量为[158.4(142.2,180.6)]μm 2高于化疗后患者的[112.6(106.4,116.6)]μm 2,差异具有统计学意义(P<0.05)。结论TAP是乳腺癌诊断的敏感指标,在乳腺癌化疗前后疗效及预后判断中具有一定的临床应用价值,其作用机制尚未明确,需要进一步研究。
Objective To investigate the expression of tumor abnormal protein(TAP)in different types of breast cancer patients and its relationship with the clinical significance.Methods A total of one hundred and seven with breast cancer patients,who has been diagnosed by surgery from June 2017 to October 2020 were selected.The venous blood was collected to detect the maximum area of TAP aggregates.The difference of TAP expression was compared among the patients with different clinicopathological characteristics.The clinical value of TAP was explored.Results The positive rate TAP in the patients with breast cancer before chemotherapy was higher than that after chemotherapy(72.0%vs.16.8%).The positive rate of TAP in the patients with axillary lymph nodes metastasis were higher than that of the ones without metastasis(84.0%vs.61.4%),the difference was statistically significant(P<0.05).The positive rate of TAP in patients with large tumor diameter and high expression of Ki-67 were higher than those of in the patients with small tumor diameter and low expression level of Ki-67(P<0.05).However,there was no significant difference in the TAP level among the patients with different gender,age,expressions of ER,PR,Her-2,E-cad,CK5/6,neoplasm staging and distant metastases(P>0.05).The relative expression level of TAP agglomerate area in patients before chemotherapy was(158.4[142.2,180.6])μm 2 which was higher than that in patients after chemotherapy(112.6[106.4,116.6])μm 2 significantly(P<0.05).Conclusions TAP is a sensitive indicator for breast cancer diagnosis.TAP is of a certain significance in the evaluation of chemotherapy treatment effect of breast cancer,which needs the further study.
作者
薛金秋
顾朱彤
徐凛峰
XUE Jinqiu;GU Zhutong;XU Linfeng(Department of Breast Surgery,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China)
出处
《中国肿瘤外科杂志》
CAS
2022年第1期78-81,共4页
Chinese Journal of Surgical Oncology
基金
南京医科大学科技发展基金(2014NJMU131)。
关键词
血清肿瘤异常蛋白
乳腺癌
化疗疗效
临床特征
Tumor abnormal protein
Breast cancer
chemotherapy
Clinical characteristic