肝癌患者化疗栓塞术后早期外周血免疫细胞的变化

目的观察原发性肝癌(HCC)患者化疗栓塞术后外周血免疫细胞的变化.方法回顾分析36例行化疗栓塞术的HCC患者在手术前24h内和术后72~96h外周血免疫细胞的数据,比较手术前后的变化.结果HCC患者外周血中表型为CD45modCD11b^(+)CD14^(-)CD15^(-)的细胞化疗前后差异有统计学意义(Z=-3.131,P=0.002),而调节性T细胞和T淋巴细胞亚群的前后差异均无统计学意义(P>0.05).结论CD45modCD11b^(+)CD14^(-)CD15^(-)细胞可能在HCC患者接收化疗栓塞术后早期对患者的疗效监测和预后判断具有重要意义.

Objective To investigate the change and clinical significance of peripheral blood immune cells in patients with hepatocellular carcinoma(HCC)after chemoembolization.Methods Retrospectively analyze the peripheral blood immune cell analysis results of 36 patients with HCC undergoing chemoembolization in the 24 hours before the operation and 72~96 hours after the operation,and comparatively analyze the change before and after the operation.Results There were significant difference in the peripheral blood of HCC patients between before and after chemotherapy(Z=-3.131,P=0.002),but the difference of Treg and T lymphocyte subsets between the two was not statistically significant(P>0.05).Conclusions CD45modCD11b^(+)CD14^(-)CD15^(-) cells might have an important significance in early postoperative monitoring and prognosis of patients with HCC after chemotherapy.