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刘氏菖郁汤对缺血性脑卒中风痰阻络证患者神经功能缺损和依赖程度的影响 被引量:6

Effect of LIU’s Changyu Decoction on the Neurological Deficit and the Dependence Degree of Ischemic Stroke Patients with Wind and Phlegm Obstructing Channel
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摘要 目的观察刘氏菖郁汤改善缺血性脑卒中风痰阻络证患者神经功能缺损以及降低患者依赖程度的临床疗效。方法采用单中心前瞻性随机对照盲法评价方法,纳入缺血性脑卒中风痰阻络证患者共204例,对照组、醒脑静组、刘氏菖郁汤组、刘氏菖郁汤合醒脑静组各51例。对照组按缺血性脑卒中指南进行治疗,醒脑静组、刘氏菖郁汤组、刘氏菖郁汤合醒脑静组在此基础上分别联用10天醒脑静注射液、刘氏菖郁汤、刘氏菖郁汤合醒脑静注射液。以美国国立卫生研究院卒中量表(NIHSS)评定神经功能缺损、简化改良Rankin评分问卷(smRSq)进行90天依赖情况随访。结果与干预前比较,干预10天后,刘氏菖郁汤组、醒脑静组、刘氏菖郁汤合醒脑静组NIHSS评分下降(P<0.05);神经功能缺损改善有效率,刘氏菖郁汤组、醒脑静组、刘氏菖郁汤合醒脑静组均优于对照组(P<0.0083)。90天后刘氏菖郁汤组依赖情况低于对照组(P<0.0083);刘氏菖郁汤合醒脑静组有低于对照组的趋势(P=0.02);与对照组比较,刘氏菖郁汤组获得生活自理的比值比为3.1[95%CI(1.406,7.747)]。结论缺血性脑卒中风痰阻络证患者早期使用刘氏菖郁汤10天能减轻神经功能缺损;可降低90天时患者的依赖程度,提高生活自理能力。 Objective To observe the efficacy of whether LIU’s Changyu Decoction(LCYD) improvd functional deficit and reducd dependence of ischemic stroke patients with wind and phlegm obstructing channel syndrome(WPOCS). Methods Adopted was a single-center prospective randomized controlled blind evaluation method. A total of 204 ischemic stroke patients with WPOCS were included and assigned to 4 groups, i.e., the control group, Xingnaojing group(XNJ), LCYD group, LCYD+XNJ group, 51 cases in each group.Patients in the control group were treated according to the guideline of ischemic stroke as the basic treatment.Patients in the remaining three groups additionally received XNJ Injection, LCYD, LCYD+XNJ injection for 10 days, respectively. The National Institute of Health Stroke Scale(NIHSS) and the simplified modified Rankin Scale Questionnaire(smRSq) were used for neurological dysfunction assessment and 90-day dependence follow-ups.Results After 10 days of intervention, the NIHSS scores decreased significantly more than before intervention in LCYD group, XNJ group, LCYD+XNJ group(P<0.05). In terms of the effective rate of improving neurological deficits, better effects were obtained in LCYD group, XNJ group, LCYD+XNJ group than in the control group(P<0.0083). After 90 days the dependence degree was lower in LCYD group than in the control group(P<0.0083).The dependence degree showed a lower tendency in LCYD+XNJ group than in the control group(P=0.02)..Compared with the control group, the odds ratio in getting self-care of LCYD group was 3.1 [95%CI(1.406,7.747)]Conclusions Early use of LCYD for 10 days in ischemic stroke patients with WPOCS attenuated neurological deficits. It reduced the patient’s dependence at 90 days and improved self-care ability.
作者 彭皓均 庾国桢 杨小梅 皮立宏 王琛 何思颖 何灵玲 刘亚敏 沈强 吴智兵 林培政 PENG Hao-jun;YU Guo-zhen;YANG Xiao-mei;PI Li-hong;WANG Chen;HE Si-ying;HE Ling-ling;LIU Ya-min;SHEN Qiang;WU Zhi-bin;LIN Pei-zhe(Department of Encephalopathy,First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou(510405);Department of Encephalopathy,Dongguan TCM Hospital,Guangdong(523000);Department of Internal Medicine,Tianjin Dekang Tang Clinic of Tradition Chinese Medicine,Tianjin(300450))
出处 《中国中西医结合杂志》 CAS CSCD 北大核心 2022年第1期18-23,共6页 Chinese Journal of Integrated Traditional and Western Medicine
基金 广东省中医药局面上项目(No.20211141) 广东省首批名中医师承项目(No.粤中医函[2015]20号) 广州中医药大学教育研究课题(No.A3-0433-171-035)。
关键词 刘氏菖郁汤 缺血性脑卒中 化痰开窍 神经功能缺损 简化改良Rankin评分问卷 LIU’s Changyu Decoction cerebral ischemic stroke dissipating phlegm for resuscitation neurological deficit simplified modified Rankin Scale Questionnaire
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