肾功能不全与静脉血栓栓塞症

Renal insufficiency and venous thromboembolism

静脉血栓栓塞症(VTE)是临床常见、多发病。肾功能不全发生率高而病程隐匿,患者常存在凝血系统功能异常。近年来研究发现,肾功能不全患者VTE发病率高,同时合并肾功能不全或慢性肾脏病的患者VTE发病率以及不良结局发生率均升高,提示肾功能不全是影响VTE预后的重要因素。肾功能情况亦是影响VTE诊断手段选择和药物剂量调整的重要因素。本文拟就肾功能不全与VTE的发病、机制、转归以及对诊治的影响等方面,结合国内外研究的最新进展进行综述,为VTE临床防治提供线索。

Venous thromboembolism(VTE)is of high incidence and prevalence worldwide.Renal insufficiency has high disease burden with insidious development and is accompanied with disorder of coagulation system.A higher prevalence of VTE has been observed among patients with renal insufficiency whereas VTE patient with renal insufficiency had higher rates of adverse outcomes.Recent evidence indicated that renal insufficiency was an important risk factor for both short and long-term prognosis for VTE.Renal function also affects the choice of anticoagulation therapy and dosage adjustment of drugs.We conducted a comprehensive review of the pathogenesis,mechanism,prognosis and treatment strategy for VTE patients who comorbid renal insufficiency by searching the latest and most advanced national and international articles,to provide integrated information for the prevention and treatment for VTE patients.