生酮饮食对肥胖型哮喘的影响

Effect of ketogenic diet on obesity asthma

肥胖和支气管哮喘(以下简称哮喘)之间的相关性日益受到关注,70%难治性哮喘患者超重或肥胖,肥胖已成为哮喘的重要危险因素。近年来,生酮饮食作为自然疗法之一,被证实有治疗肥胖症的作用,并且也有研究指出生酮饮食可降低哮喘气道炎症。本文总结了肥胖与哮喘的关联机制,阐述了生酮饮食影响肥胖型哮喘的潜在机制,如控制体重,减轻炎症反应,调节肠道菌群和修饰表观遗传,为肥胖型哮喘的防治提供新的思路。

Recently investigators pay more attention to the relationship between obesity and bronchial asthma(asthma).Obesity is increasingly recognized as a possible risk factor for childhood asthma,and 70%of patients with difficult-to-treat asthma are overweight or obese.In recent years,ketogenic diet,as one of the natural therapies,has been shown to have positive effects on weight loss process;and recent studies showed that ketogenic diet reduced airway inflammation in asthma.This review summarized the mechanisms of associations between obesity and asthma,and described the potential mechanisms of ketogenic diet affecting obese asthma,such as controlling body weight,reducing inflammatory response,regulating intestinal flora and modifying epigenetics,to provide new ideas for the prevention and treatment of obesity asthma.